Actively Recruiting
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Led by Yale University · Updated on 2026-05-08
700
Participants Needed
187
Research Sites
374 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF). Secondary Aim: To determine if apixaban, compared with aspirin, results in better functional outcomes as measured by the modified Rankin Scale.
CONDITIONS
Official Title
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age at least 18 years
- Intracerebral hemorrhage (including primary intraventricular hemorrhage) confirmed by brain CT or MRI
- Can be randomized within 14 to 180 days after ICH onset
- Non-valvular atrial fibrillation or atrial flutter documented by electrocardiography or physician-confirmed history
- Signed and dated informed consent form by patient or legally authorized representative
- For females of reproductive potential: use of highly effective contraception
You will not qualify if you...
- Hemorrhagic transformation of a brain infarction or hemorrhage into a tumor as index event
- History of ICH within 12 months before the index event
- Active infective endocarditis
- Clear indication for anticoagulant or antiplatelet drugs for other conditions
- Previous or planned left atrial appendage closure
- Clinically significant bleeding disorder
- Serum creatinine 2.5 mg/dL or higher
- Active hepatitis or hepatic insufficiency with Child-Pugh score B or C
- Chronic anemia (hemoglobin less than 8 g/dL) or thrombocytopenia (less than 100 x 10^9/L)
- Pregnant or breastfeeding
- Known allergy to aspirin or apixaban
- Participation in another competing trial
- Condition that precludes safe or active participation as judged by investigator
- Persistent, uncontrolled systolic blood pressure 180 mm Hg or higher
- ICH caused by unsecured arteriovenous malformation (AVM)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 187 locations
1
University of Alabama Hospital
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
University of South Alabama University Hospital
Mobile, Alabama, United States, 36604
Actively Recruiting
3
Chandler Regional Medical Center
Chandler, Arizona, United States, 85224
Withdrawn
4
St. Joseph's Hospital and Medical Center
Phoenix, Arizona, United States, 85013
Withdrawn
5
Banner University Medical Center
Tucson, Arizona, United States, 85719
Actively Recruiting
6
UAMS Medical Center
Little Rock, Arkansas, United States, 77205
Withdrawn
7
Mercy San Juan Medical Center
Carmichael, California, United States, 95608
Actively Recruiting
8
Eden Medical Center, Castro Valley
Castro Valley, California, United States, 94546
Withdrawn
9
Arrowhead Regional Medical Center
Colton, California, United States, 92324
Actively Recruiting
10
Rancho Los Amigos National Rehabilitation Center
Downey, California, United States, 90242
Suspended
11
Kaiser Permanente Fontana Medical Center
Fontana, California, United States, 92335
Actively Recruiting
12
Community Regional Medical Center of Fresno
Fresno, California, United States, 93720
Actively Recruiting
13
St. Jude Medical Center
Fullerton, California, United States, 92835
Actively Recruiting
14
Long Beach Memorial Medical Center
Long Beach, California, United States, 90806
Withdrawn
15
Los Alamitos Medical Center
Los Alamitos, California, United States, 90720
Actively Recruiting
16
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States, 90027
Actively Recruiting
17
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
18
Ronald Reagan UCLA Medical Center
Los Angeles, California, United States, 90095
Actively Recruiting
19
Doctors Medical Center Modesto, Modesto, CA
Modesto, California, United States, 95350
Actively Recruiting
20
Hoag Hospital Newport Beach
Newport Beach, California, United States, 92663
Withdrawn
21
UC Irvine Medical Center
Orange, California, United States, 92868
Actively Recruiting
22
Desert Regional Medical Center
Palm Springs, California, United States, 92262
Actively Recruiting
23
Huntington Memorial Hospital
Pasadena, California, United States, 91105
Withdrawn
24
Kaiser Permanente Redwood City Medical Center, Redwood City, CA
Redwood City, California, United States, 94063
Actively Recruiting
25
UC Davis Medical Center
Sacramento, California, United States, 95817
Actively Recruiting
26
Kaiser Permanente Sacramento Medical Center
Sacramento, California, United States, 95825
Actively Recruiting
27
San Francisco General Hospital
San Francisco, California, United States, 94110
Actively Recruiting
28
Santa Barbara Cottage Hospital
Santa Barbara, California, United States, 93105
Actively Recruiting
29
Stanford University Medical Center
Stanford, California, United States, 94304
Actively Recruiting
30
PIH Health Hospital - Whittier
Whittier, California, United States, 90602
Actively Recruiting
31
University of Colorado Hospital
Aurora, Colorado, United States, 80045
Actively Recruiting
32
St. Mary's Medical Center
Grand Junction, Colorado, United States, 81501
Withdrawn
33
Danbury Hospital
Danbury, Connecticut, United States, 06810
Suspended
34
Hartford Hospital
Hartford, Connecticut, United States, 06102
Actively Recruiting
35
Yale New Haven Hospital
New Haven, Connecticut, United States, 06511
Actively Recruiting
36
New Hanover Regional Medical Center
Wilmington, Delaware, United States, 28403
Actively Recruiting
37
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
38
MedStar Washington Hospital Center
Washington D.C., District of Columbia, United States, 20010
Withdrawn
39
George Washington University Hospital
Washington D.C., District of Columbia, United States, 20037
Actively Recruiting
40
Morton Plant Hospital
Clearwater, Florida, United States, 33756
Actively Recruiting
41
Broward Health Medical Center
Fort Lauderdale, Florida, United States, 33316
Actively Recruiting
42
UF Health Jacksonville
Jacksonville, Florida, United States, 32209
Actively Recruiting
43
Mayo Clinic
Jacksonville, Florida, United States, 32224
Terminated
44
Jackson Memorial Hospital
Miami, Florida, United States, 33136
Actively Recruiting
45
Ascension Sacred Heart Pensacola
Pensacola, Florida, United States, 32504
Actively Recruiting
46
Cleveland Clinic Tradition Hospital
Port Saint Lucie, Florida, United States, 34987
Actively Recruiting
47
Tampa General Hospital
Tampa, Florida, United States, 33606
Actively Recruiting
48
St. Joseph's Hospital
Tampa, Florida, United States, 33607
Actively Recruiting
49
Grady Memorial Hospital
Atlanta, Georgia, United States, 30303
Actively Recruiting
50
Emory University Hospital
Atlanta, Georgia, United States, 30322
Actively Recruiting
51
Augusta University Medical Center
Augusta, Georgia, United States, 30912
Actively Recruiting
52
WellStar Kennestone Hospital
Marietta, Georgia, United States, 30060
Actively Recruiting
53
The Queen's Medical Center
Honolulu, Hawaii, United States, 96813
Actively Recruiting
54
Saint Alphonsus Regional Medical Center - Boise
Boise, Idaho, United States, 83706
Actively Recruiting
55
NCH Hospital, Arlington Heights
Arlington Heights, Illinois, United States, 60005
Actively Recruiting
56
Rush University Medical Center
Chicago, Illinois, United States, 60612
Actively Recruiting
57
University of Illinois Hospital
Chicago, Illinois, United States, 60612
Actively Recruiting
58
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
59
Evanston Hospital
Evanston, Illinois, United States, 60201
Actively Recruiting
60
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Actively Recruiting
61
OSF St. Francis Medical Center
Peoria, Illinois, United States, 61637
Actively Recruiting
62
Javon Bea Hospital - Riverside
Rockford, Illinois, United States, 61114
Withdrawn
63
St. John's Hospital
Springfield, Illinois, United States, 62769
Withdrawn
64
Central DuPage Hospital
Winfield, Illinois, United States, 60190
Actively Recruiting
65
IU Health Methodist Hospital
Indianapolis, Indiana, United States, 46202
Actively Recruiting
66
University of Iowa Medical Center
Iowa City, Iowa, United States, 52242
Actively Recruiting
67
University of Kansas Hospital
Kansas City, Kansas, United States, 66160
Actively Recruiting
68
Baptist Health Lexington
Lexington, Kentucky, United States, 40503
Actively Recruiting
69
University of Kentucky Hospital
Lexington, Kentucky, United States, 40536
Actively Recruiting
70
University of Louisville Hospital
Louisville, Kentucky, United States, 40202
Actively Recruiting
71
Ochsner Medical Center - Main Campus
New Orleans, Louisiana, United States, 70121
Actively Recruiting
72
Eastern Maine Medical Center
Bangor, Maine, United States, 04401
Withdrawn
73
Maine Medical Center
Portland, Maine, United States, 04102
Actively Recruiting
74
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
75
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
76
Boston Medical Center
Boston, Massachusetts, United States, 02118
Actively Recruiting
77
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
78
Lahey Hospital & Medical Center
Burlington, Massachusetts, United States, 01805
Actively Recruiting
79
Baystate Medical Center
Springfield, Massachusetts, United States, 01199
Actively Recruiting
80
UMass Memorial Medical Center
Worcester, Massachusetts, United States, 01655
Actively Recruiting
81
University of Michigan University Hospital
Ann Arbor, Michigan, United States, 48109
Withdrawn
82
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Withdrawn
83
McLaren Flint
Flint, Michigan, United States, 48532
Withdrawn
84
Trinity Health Saint Mary's
Grand Rapids, Michigan, United States, 49503
Withdrawn
85
Trinity Health Saint Mary's
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
86
McLaren Macomb
Mount Clemens, Michigan, United States, 48043
Terminated
87
Munson Medical Center
Traverse City, Michigan, United States, 49684
Actively Recruiting
88
Metro Health Hospital
Wyoming, Michigan, United States, 49519
Withdrawn
89
Abbott Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
90
M Health Fairview University of Minnesota Medical Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
91
St. Cloud Hospital
Saint Cloud, Minnesota, United States, 56303
Actively Recruiting
92
HealthPartners Methodist Hospital
Saint Louis Park, Minnesota, United States, 55426
Active, Not Recruiting
93
Regions Hospital
Saint Paul, Minnesota, United States, 55101
Terminated
94
United Hospital, St. Paul
Saint Paul, Minnesota, United States, 55102
Withdrawn
95
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Withdrawn
96
University of Missouri Health Care
Columbia, Missouri, United States, 65212
Actively Recruiting
97
Mercy Hospital Springfield
Springfield, Missouri, United States, 65804
Actively Recruiting
98
Cox Medical Center South
Springfield, Missouri, United States, 65807
Actively Recruiting
99
Barnes Jewish Hospital
St Louis, Missouri, United States, 63110
Actively Recruiting
100
Mercy Hospital South
St Louis, Missouri, United States, 63128
Actively Recruiting
101
Mercy Hospital St. Louis
St Louis, Missouri, United States, 63141
Actively Recruiting
102
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68105
Actively Recruiting
103
JFK Medical Center
Edison, New Jersey, United States, 08820
Actively Recruiting
104
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
105
Cooperman Barnabas Medical Center
Livingston, New Jersey, United States, 07052
Actively Recruiting
106
Jersey Shore University Medical Center
Neptune City, New Jersey, United States, 07753
Actively Recruiting
107
Overlook Medical Center
Summit, New Jersey, United States, 07901
Actively Recruiting
108
Capital Health Regional Medical Center
Trenton, New Jersey, United States, 08638
Withdrawn
109
University of New Mexico Hospital
Albuquerque, New Mexico, United States, 87106
Suspended
110
Albany Medical Center
Albany, New York, United States, 12208
Actively Recruiting
111
Kings County Hospital Center
Brooklyn, New York, United States, 11203
Actively Recruiting
112
NewYork-Presbyterian Brooklyn Methodist Hospital
Brooklyn, New York, United States, 11215
Withdrawn
113
Maimonides Medical Center
Brooklyn, New York, United States, 11219
Terminated
114
NYU Langone Hospital - Brooklyn
Brooklyn, New York, United States, 11220
Actively Recruiting
115
Buffalo General Medical Center
Buffalo, New York, United States, 14202
Active, Not Recruiting
116
NYC Health + Hospitals/Elmhurst
Elmhurst, New York, United States, 11373
Actively Recruiting
117
North Shore University Hospital
Manhasset, New York, United States, 11030
Actively Recruiting
118
Mount Sinai West
New York, New York, United States, 10019
Actively Recruiting
119
The Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
120
NYP Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
121
NYP Weill Cornell Medical Center
New York, New York, United States, 10065
Actively Recruiting
122
Vassar Brothers Medical Center
Poughkeepsie, New York, United States, 12601
Terminated
123
Strong Memorial Hospital
Rochester, New York, United States, 14642
Actively Recruiting
124
Staten Island University Hospital - North Campus
Staten Island, New York, United States, 10305
Withdrawn
125
Stony Brook University Hospital
Stony Brook, New York, United States, 11794
Actively Recruiting
126
SUNY Upstate Medical University
Syracuse, New York, United States, 13210
Actively Recruiting
127
Montefiore Medical Center
The Bronx, New York, United States, 10467
Actively Recruiting
128
Westchester Medical Center
Valhalla, New York, United States, 10595
Actively Recruiting
129
Burke Rehabilitation Center
White Plains, New York, United States, 10605
Actively Recruiting
130
University of North Carolina Medical Center
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
131
Carolinas Medical Center
Charlotte, North Carolina, United States, 28204
Withdrawn
132
Presbyterian Medical Center
Charlotte, North Carolina, United States, 28204
Actively Recruiting
133
Duke University Hospital
Durham, North Carolina, United States, 27710
Actively Recruiting
134
Moses H. Cone Memorial Hospital
Greensboro, North Carolina, United States, 27401
Actively Recruiting
135
ECU Health Medical Center
Greenville, North Carolina, United States, 27834
Actively Recruiting
136
New Hanover Regional Medical Center
Wilmington, North Carolina, United States, 28403
Actively Recruiting
137
Forsyth Medical Center
Winston-Salem, North Carolina, United States, 27103
Actively Recruiting
138
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
139
Cleveland Clinic Akron General
Akron, Ohio, United States, 44307
Actively Recruiting
140
University of Cincinnati Medical Center
Cincinnati, Ohio, United States, 45219
Actively Recruiting
141
Good Samaritan Hospital
Cincinnati, Ohio, United States, 45220
Actively Recruiting
142
UH Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
143
MetroHealth Medical Center
Cleveland, Ohio, United States, 44109
Actively Recruiting
144
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
145
OSU Wexner Medical Center
Columbus, Ohio, United States, 43210
Actively Recruiting
146
Riverside Methodist Hospital
Columbus, Ohio, United States, 43214
Actively Recruiting
147
OU Medical Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
148
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, United States, 73120
Actively Recruiting
149
Ascension St. John Medical Center
Tulsa, Oklahoma, United States, 74104
Actively Recruiting
150
St. John Medical Center
Tulsa, Oklahoma, United States, 74104
Actively Recruiting
151
Oregon Health & Science University Hospital
Portland, Oregon, United States, 92739
Actively Recruiting
152
Providence St. Vincent Medical Center
Portland, Oregon, United States, 97213
Actively Recruiting
153
PeaceHealth Sacred Heart Medical Center - RiverBend
Springfield, Oregon, United States, 97477
Actively Recruiting
154
Jefferson Abington Hospital
Abington, Pennsylvania, United States, 19001
Actively Recruiting
155
Lehigh Valley Hospital - Cedar Crest
Allentown, Pennsylvania, United States, 18103
Withdrawn
156
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822
Withdrawn
157
Penn State Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
158
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
159
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States, 19107
Withdrawn
160
Temple University Hospital
Philadelphia, Pennsylvania, United States, 19140
Actively Recruiting
161
UPMC Presbyterian Hospital
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
162
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
Terminated
163
Medical University of South Carolina University Hospital
Charleston, South Carolina, United States, 29425
Actively Recruiting
164
Greenville Hospital System
Greenville, South Carolina, United States, 29605
Actively Recruiting
165
Avera Research Institute
Sioux Falls, South Dakota, United States, 57108
Actively Recruiting
166
Erlanger Health System
Chattanooga, Tennessee, United States, 37403
Withdrawn
167
Fort Sanders Regional Medical Center
Knoxville, Tennessee, United States, 37916
Actively Recruiting
168
Methodist University Hospital
Memphis, Tennessee, United States, 38104
Actively Recruiting
169
Semmes Murphey Main Campus
Memphis, Tennessee, United States, 38120
Actively Recruiting
170
Vanderbilt University Hospital
Nashville, Tennessee, United States, 37232
Actively Recruiting
171
St. David's Medical Center
Austin, Texas, United States, 78705
Withdrawn
172
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Withdrawn
173
Baylor College of Medicine Medical Center
Houston, Texas, United States, 77030
Withdrawn
174
Houston Methodist Hospital
Houston, Texas, United States, 77030
Actively Recruiting
175
Memorial Hermann Texas Medical Center
Houston, Texas, United States, 77030
Actively Recruiting
176
University of Texas Health Science Center San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
177
University of Utah Healthcare
Salt Lake City, Utah, United States, 84112
Actively Recruiting
178
The University of Vermont Medical Center
Burlington, Vermont, United States, 05401
Actively Recruiting
179
UVA Medical Center
Charlottesville, Virginia, United States, 22908
Actively Recruiting
180
Inova Fairfax Hospital
Falls Church, Virginia, United States, 22042
Actively Recruiting
181
Bon Secours St. Mary's Hospital
Richmond, Virginia, United States, 23226
Actively Recruiting
182
VCU Medical Center
Richmond, Virginia, United States, 23298
Suspended
183
Virginia Mason Medical Center
Seattle, Washington, United States, 98101
Withdrawn
184
Harborview Medical Center
Seattle, Washington, United States, 98104
Actively Recruiting
185
Swedish Medical Center - Cherry Hill Campus
Seattle, Washington, United States, 98122
Withdrawn
186
J.W. Ruby Memorial Hospital
Morgantown, West Virginia, United States, 26506
Actively Recruiting
187
Froedtert Hospital
Milwaukee, Wisconsin, United States, 53226
Withdrawn
Research Team
K
Kevin N Sheth, MD
CONTACT
H
Hooman Kamel, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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