Actively Recruiting
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
Led by Population Health Research Institute · Updated on 2026-01-12
2270
Participants Needed
105
Research Sites
494 weeks
Total Duration
On this page
Sponsors
P
Population Health Research Institute
Lead Sponsor
H
Hamilton Health Sciences Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Multinational, investigator-initiated study of oral anticoagulation versus no anticoagulation for the prevention of stroke and other adverse cardiovascular events in patients with transient atrial fibrillation occurring transiently with stress and additional stroke risk factors.
CONDITIONS
Official Title
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have had at least one episode of clinically important atrial fibrillation occurring transiently with stress within the past 35 days related to either noncardiac surgery with overnight hospital stay, noncardiac day surgery causing significant physiological stress, or acute medical illness requiring hospital admission
- Are in sinus rhythm at the time of randomization
- Meet one of the following high-risk criteria:
- Age 55-64 years with known cardiovascular disease, recent major vascular surgery, a CHA2DS2VASc score of 3 or more, or elevated postoperative troponin
- Age 65-74 years with known cardiovascular disease, recent major vascular surgery, a CHA2DS2VASc score of 2 or more, or elevated postoperative troponin
- Age 75 years or older
- Provide written informed consent
You will not qualify if you...
- Have any cardiac diagnosis as the primary reason for hospital admission
- Have a history of documented chronic atrial fibrillation before noncardiac surgery
- Require long-term systemic anticoagulation
- Require long-term dual antiplatelet treatment
- Have contraindications to oral anticoagulation
- Have severe renal insufficiency (creatinine clearance less than 20 ml/min)
- Have severe liver cirrhosis (Child-Pugh Class C)
- Had an acute stroke in the past 14 days
- Had cardiac surgery in the past 35 days
- Have a history of nontraumatic intracranial, intraocular, or spinal bleeding
- Have hemorrhagic disorder or bleeding tendency
- Are expected to be non-compliant with follow-up or study medications
- Have a life expectancy less than 1 year due to other diseases
- Are women who are pregnant, breastfeeding, or of childbearing potential not using effective contraception
- Were previously enrolled in this trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 105 locations
1
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
2
Mcgovern Medical School at University of Texas
Houston, Texas, United States, 77030
Actively Recruiting
3
Clinica Coronel Suarez
Coronel Suárez, Buenos Aires, Argentina, 7540
Actively Recruiting
4
Instituto de Investigaciones Clinicas Rosario
Rosario, Santa Fe Province, Argentina, 2000
Actively Recruiting
5
Instituto Cardiovascular de Rosario
Rosario, Santa Fe Province, Argentina, S2000
Actively Recruiting
6
Centro Integral de Arritmias de Tucuman (CIAT)
San Miguel de Tucumán, Tucumán Province, Argentina, 4000
Actively Recruiting
7
Hospital Municipal Chivilcoy
Chivilcoy, Argentina, B6620
Actively Recruiting
8
Sanatorio Cisma
San Miguel de Tucumán, Argentina, T4000
Actively Recruiting
9
Hospital Privado de Rosario
Santa Fe, Argentina, S2000GAP
Not Yet Recruiting
10
Canberra Hospital
Garran, Australian Capital Territory, Australia, 2605
Actively Recruiting
11
Bankstown Hospital
Bankstown, New South Wales, Australia, 2200
Actively Recruiting
12
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia, 2050
Actively Recruiting
13
Concord Repatriation General Hospital
Concord, New South Wales, Australia, 2139
Actively Recruiting
14
Liverpool Hospital
Liverpool, New South Wales, Australia, 2170
Not Yet Recruiting
15
John Hunter Hospital
Newcastle, New South Wales, Australia, 2305
Actively Recruiting
16
Westmead Hospital
Westmead, New South Wales, Australia, 2145
Actively Recruiting
17
Sunshine Coast Hospital and Health Service
Birtinya, Queensland, Australia, 4575
Actively Recruiting
18
Royal Brisbane and Women's Hospital
Herston, Queensland, Australia, 4029
Not Yet Recruiting
19
Redcliffe Hospital
Redcliffe, Queensland, Australia, 4020
Actively Recruiting
20
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
Not Yet Recruiting
21
Box Hill Hospital
Box Hill, Victoria, Australia, 3128
Actively Recruiting
22
Northeast Health Wangaratta
Wangaratta, Victoria, Australia, 3677
Actively Recruiting
23
Royal Perth Hospital
Perth, Western Australia, Australia, 6000
Actively Recruiting
24
Instituto do Coração do Hospital das Clínicas da FMUSP
Cerqueira César, Brazil, 05403-900
Actively Recruiting
25
Hospital de Clinicas de Porto Alegre
Porto Alegre, Brazil, 90035-903
Actively Recruiting
26
Foothills Hospital
Calgary, Alberta, Canada, T2N 2T9
Actively Recruiting
27
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
28
Medicine Hat Regional Hospital
Medicine Hat, Alberta, Canada, T1A 4H6
Actively Recruiting
29
East Kootenay Regional Hospital
Cranbrook, British Columbia, Canada, V1C 3H9
Not Yet Recruiting
30
Fraser Health Authority
Surrey, British Columbia, Canada, V3V 1Z2
Actively Recruiting
31
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1N1
Actively Recruiting
32
Health Sciences Centre Winnipeg
Winnipeg, Manitoba, Canada, R3A 1R9
Actively Recruiting
33
Dr.-Georges-L.-Dumont University Hospital Centre
Moncton, New Brunswick, Canada, E1C 2Z3
Not Yet Recruiting
34
Halifax Infirmary
Halifax, Nova Scotia, Canada, B3H 3A6
Actively Recruiting
35
Cape Breton University
Sydney, Nova Scotia, Canada, B1M 1A2
Actively Recruiting
36
Cambridge Cardiac Care Centre
Cambridge, Ontario, Canada, N1R 6V6
Not Yet Recruiting
37
Hamilton General Hospital
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
38
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada, L8N 4A6
Actively Recruiting
39
Juravinski Hospital
Hamilton, Ontario, Canada, L8V 1C3
Actively Recruiting
40
Kingston General Hospital
Kingston, Ontario, Canada, K7L 2V7
Actively Recruiting
41
London Health Sciences Centre - University Hospital
London, Ontario, Canada, N6A 5A5
Actively Recruiting
42
The Ottawa Hospital General Campus
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
43
Niagara Health System - St. Catharine's Site
St. Catharines, Ontario, Canada, L2S 0A9
Actively Recruiting
44
Cortelluci Vaughan Hospital
Vaughan, Ontario, Canada, L6A 4Z3
Actively Recruiting
45
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada, H2X 3E4
Actively Recruiting
46
CHU de Quebec Universite Laval
Québec, Quebec, Canada, G1R 2J6
Not Yet Recruiting
47
Hôpital Fleurimont du Centre hospitalier universitaire de Sherbrooke
Sherbrooke, Quebec, Canada, J1H 5H3
Actively Recruiting
48
Regina General Hospital
Regina, Saskatchewan, Canada, S4P 0W5
Actively Recruiting
49
Royal University Hospital
Saskatoon, Saskatchewan, Canada, S7N 0W8
Actively Recruiting
50
Aarhus University Hospital
Aarhus, Denmark, 8200
Actively Recruiting
51
Hospital South West Jutland - University Hospital of Southern Denmark
Esbjerg, Denmark, 6700
Actively Recruiting
52
Odense University Hospital
Odense, Denmark, 5000
Actively Recruiting
53
Southwest Finland Wellbeing County (VARHA)
Turku, Finland, 20520
Actively Recruiting
54
Universitatsklinikum Leipzig
Leipzig, Germany, 04103
Actively Recruiting
55
GNRC Medical
North Guwāhāti, Assam, India, 781031
Not Yet Recruiting
56
Marengo CIMS Hospital
Ahmedabad, Gujarat, India, 380060
Not Yet Recruiting
57
NU Hospitals
Bangalore, Karnataka, India, 560010
Actively Recruiting
58
Govt. T.D. Medical College
Alappuzha, Kerala, India, 688005
Not Yet Recruiting
59
Amala Institute of Medical Sciences
Thrissur, Kerala, India, 680555
Actively Recruiting
60
Amala Institute
Thrissur, Kerala, India, 680555
Not Yet Recruiting
61
St. John's Medical College Hospital
Bangalore, India, 560034
Actively Recruiting
62
JIPMER
Puducherry, India, 605006
Actively Recruiting
63
Ruby Hall Clinic
Pune, India, 411057
Not Yet Recruiting
64
Trivandrum Medical
Thiruvananthapuram, India, 695011
Actively Recruiting
65
ASST Grande Ospedale Metropolitano Niguarda
Milan, Milan, Italy, 20162
Actively Recruiting
66
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
Alessandria, Italy, 15121
Actively Recruiting
67
Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico
Milan, Italy, 20122
Actively Recruiting
68
La Maddalena
Palermo, Italy, 90146
Actively Recruiting
69
Piacenza Ospedale
Piacenza, Italy, 29121
Actively Recruiting
70
Nobel Medical College Teaching Hospital
Biratnagar, Nepal, 56700
Actively Recruiting
71
B.P. Koirala Institute of Health Sciences
Koshi, Nepal, 56700
Actively Recruiting
72
B and B Hospital
Lalitpur, Nepal, 44700
Actively Recruiting
73
Jeroen Bosch Hospital
's-Hertogenbosch, Netherlands, 5223
Actively Recruiting
74
Noordwest Ziekenhuisgroep
Alkmaar, Netherlands, 1815
Actively Recruiting
75
ZiekenhuisGroepTwente (ZGT)
Almelo, Netherlands, 7609
Actively Recruiting
76
Ziekenhuis Amstelland
Amstelveen, Netherlands, 1186
Actively Recruiting
77
Rijnstate Hospital
Arnhem, Netherlands, 6815
Actively Recruiting
78
Amphia Ziekenhuis Breda
Breda, Netherlands, 4818 CK
Actively Recruiting
79
Deventer Ziekenhuis
Deventer, Netherlands, 7416
Actively Recruiting
80
Hospital Gelderse Vallei
Ede, Netherlands, 6716
Actively Recruiting
81
Martini Hospital
Groningen, Netherlands, 9728
Actively Recruiting
82
Franciscus Gasthuis
Rotterdam, Netherlands, 3045
Actively Recruiting
83
Ikazia Hospital
Rotterdam, Netherlands, 3083
Actively Recruiting
84
ETZ Tilburg
Tilburg, Netherlands, 5022
Actively Recruiting
85
Aga Khan University
Karachi, Sindh, Pakistan, 74000
Actively Recruiting
86
Maroof International Hospital
Islamabad, Pakistan, 04412
Actively Recruiting
87
Shifa International Hospital
Islamabad, Pakistan
Actively Recruiting
88
Dow Medical University
Karachi, Pakistan
Actively Recruiting
89
Rehman Medical Institute
Peshawar, Pakistan, 25000
Actively Recruiting
90
Korea Univesrity Anam Hospital
Seoul, South Korea, 02841
Actively Recruiting
91
Seoul National University Hospital
Seoul, South Korea, 03080
Actively Recruiting
92
Seoul National University Bundang Hospital
Seoul, South Korea, 13620
Actively Recruiting
93
Hospital de Mar
Barcelona, Barcelona, Spain, 08003
Not Yet Recruiting
94
Vall d'Hebron Hospital
Barcelona, Barcelona, Spain, 08014
Not Yet Recruiting
95
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain, 08025
Actively Recruiting
96
Hospital Mutua de Terrassa
Barcelona, Spain, 08221
Actively Recruiting
97
University Hospital Ramon y Cajal
Madrid, Spain, 28034
Actively Recruiting
98
Hospital Universitario de Navarra
Pamplona, Spain, 31008
Actively Recruiting
99
Karolinska Institutet Danderyd Hospital
Danderyd, Sweden, 18257
Actively Recruiting
100
Uppsala University
Uppsala, Sweden, 751 85
Actively Recruiting
101
University Hospital Basel
Basel, Basel, Switzerland, 4031
Actively Recruiting
102
Kantonsspital St. Gallen
Sankt Gallen, Switzerland, 9000
Actively Recruiting
103
Kantonsspital Winterthur
Winterthur, Switzerland, 8400
Actively Recruiting
104
Liverpool Heart and Chest Hospital
Liverpool, United Kingdom, L14 3PE
Actively Recruiting
105
Southend Hospital
Westcliff-on-Sea, United Kingdom, SS0 0RY
Actively Recruiting
Research Team
C
Cassie McDonald
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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