Actively Recruiting
AntiCoagulation Versus AcetylSalicylic Acid After Transcatheter Aortic Valve Implantation
Led by Oslo University Hospital · Updated on 2022-11-14
360
Participants Needed
3
Research Sites
256 weeks
Total Duration
On this page
Sponsors
O
Oslo University Hospital
Lead Sponsor
U
University of Oslo
Collaborating Sponsor
AI-Summary
What this Trial Is About
ACASA-TAVI is a pragmatic randomized controlled trial assessing the value of anticoagulation therapy versus the standard antiplatelet therapy after transcatheter aortic valve implantation in patients with aortic stenosis. The trial will assess the efficacy of direct oral anticoagulation (DOAC) therapy compared to the standard single antiplatelet therapy to prevent degeneration of the valve and its safety in co-primary endpoints with blinded endpoint adjudication. The effect of DOAC therapy on hard clinical outcomes will be assessed during long-term follow-up.
CONDITIONS
Official Title
AntiCoagulation Versus AcetylSalicylic Acid After Transcatheter Aortic Valve Implantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Successful transcatheter aortic valve implantation
- Age greater than 65 years and less than 80 years at the time of the procedure
You will not qualify if you...
- Strict indication for anticoagulation or antiplatelet drugs
- Strict contraindication for anticoagulation or antiplatelet drugs
- Overt cognitive failure
- Failure to obtain written informed consent
- Concomitant use of inducers or inhibitors of CYP3A4 or P-glycoprotein
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Haukeland University Hospital
Bergen, Norway, 5021
Not Yet Recruiting
2
Oslo Univesity Hospital - Ullevål
Oslo, Norway, 0424
Not Yet Recruiting
3
Oslo University Hospital - Rikshospitalet
Oslo, Norway, 0772
Actively Recruiting
Research Team
Ø
Øyvind H Lie, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here