Study of Olive Pomace Oil Effects on Blood Sugar and Metabolism in Adults with Diabetes or Prediabetes Includes Post-Meal and Long-Term Dietary Tests

What this Trial Is About

Researchers are evaluating whether olive pomace oil can benefit people with type 2 diabetes or those at risk of developing it, such as prediabetic individuals. The study aims to determine if olive pomace oil can prevent high blood sugar spikes after meals, lower fasting blood glucose levels when consumed daily, and improve glucose regulation along with other issues like high blood fats and inflammation. The effects of olive pomace oil will be compared to a high-oleic acid sunflower oil to assess their impact on these health measures. The study includes two parallel parts a postprandial study and a chronic intervention. In the postprandial study, participants will visit the Human Nutrition Unit on different days to consume white bread alone or with different oils extra virgin olive oil, olive pomace oil, or high-oleic acid sunflower oil while blood samples are taken to measure blood sugar and hormone responses. The chronic study is a randomized, double-blind crossover trial lasting 22 weeks, where participants consume corn oil for 3 weeks, then either olive pomace oil or sunflower oil for 8 weeks each, with a 3-week washout period of corn oil between. Participants must avoid other oils and high-fat foods during the study. Participants will visit the clinic every 4 weeks during the chronic study for health checkups including blood pressure, body weight, and blood tests. They will keep diaries of their insulin or metformin use and blood glucose measurements at home. Diet and physical activity will be monitored through questionnaires, phone interviews, and wearing an accelerometer for a week. Researchers will assess fasting and post-meal blood glucose, insulin resistance, lipid levels, inflammation markers, and other hormones to understand how olive pomace oil affects diabetes-related health measures.

Antidiabetic Effect of Olive Pomace Oil