Actively Recruiting
Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
Led by University of Florida · Updated on 2026-03-06
120
Participants Needed
1
Research Sites
181 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
E
Emory University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension. The main questions it aims to answer are: * To what extent does minocycline lower blood pressure? * Are such blood pressure effects mediated through changes in gut microbiota, gut leakiness, systemic inflammation, neuroinflammation, or some combination of these? Participants will be randomly assigned to treatment with minocycline or placebo, treated daily for 3 months, to evaluate these questions.
CONDITIONS
Official Title
Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Uncontrolled treatment-resistant hypertension defined as 24-hour ambulatory systolic BP of 125 mm Hg or higher, or diastolic BP of 80 mm Hg or higher
- Adherence to a stable antihypertensive regimen of three or more drugs including an adequately dosed diuretic for at least 14 days prior, or unable to tolerate a diuretic
- Agreement to complete all study procedures
You will not qualify if you...
- Known allergy or contraindication to minocycline or other tetracyclines
- Recent (within 3 months), ongoing, or planned use of oral antibiotics
- Estimated glomerular filtration rate (eGFR) less than 45 mL/min/1.73m2
- Known secondary hypertension
- History of hypertensive crisis requiring hospitalization within the past year
- History of two or more episodes of orthostatic hypotension in the past year
- History of heart attack, unstable angina, fainting, or stroke in the past 6 months
- Evidence of alcoholism or drug abuse
- Severe illnesses such as cancer, HIV positive status, or AIDS
- Current pregnancy or planned pregnancy during the study
AI-Screening
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Trial Site Locations
Total: 1 location
1
UF Clinical Research Center (UF CRC) - CTSI
Gainesville, Florida, United States, 32610
Actively Recruiting
Research Team
J
Joshua N Terrell
CONTACT
D
David B Smith
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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