Actively Recruiting
Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication
Led by Hadeer Maher Mostafa Mohamed · Updated on 2025-12-01
54
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Successful endodontic treatment and a predictable outcome can only be achieved by effective root canal debridement, irrigation, and elimination of microorganisms . The outcome of endodontic treatment performed in controlled clinical environment has demonstrated success rate around 90%. In certain cases, endodontic treatment may fail, one of the most common reasons is inability to eliminate microorganisms from the root canal. When non-surgical root canal therapy fails, the treatment options include orthograde re-treatment, periradicular surgery, or extraction. Simvastatin (SIM) is a drug used primarily to treat hyperlipidemia and protect against cardiovascular diseases. It has been shown to possess pleiotropic effects such as antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and bone-forming properties . The side chain of this material has a single methyl group. It inhibits hydroxymethyl glutarylcoenzyme reductase that prevents endogenous cholesterol synthesis
CONDITIONS
Official Title
Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged between 20 and 40 years old with no physical disability or psychological problems
- Patients with a non-contributory medical history
- Single-rooted teeth with type I root canal anatomy
- Symptomatic failed endodontic treatment cases with radiographic evidence of periapical bone loss
- Lesion size ranging from 2mm up to 8mm
You will not qualify if you...
- Known sensitivity to medications used in this trial
- Previous endodontic mishaps such as ledges, transportations, perforations, or separated instruments
- Non-restorable teeth
- Presence of an associated sinus tract
- Advanced periodontal involvement
- Teeth with root fractures
- Pregnant women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Faculty of Dental Medicine for Girls, Al-Azhar University
Cairo, Egypt
Actively Recruiting
Research Team
H
Hadeer Maher Mostafa Mohamed, MSc
CONTACT
M
Mervat Ibrahim Fawzy, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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