Actively Recruiting
Antimicrobial Combination Therapy for Treatment of Enterococcus Faecalis Bacteremia
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-12-03
510
Participants Needed
4
Research Sites
294 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Prospective, multicenter, national, observational pharmacological study on the evaluation of efficacy of appropriate monotherapy vs combination treatment for non-complicated Enterococcus faecalis (EF) bloodstream infection (BSI) and identification of gut microbiota fingerprint of patients with EF-BSI correlated to antimicrobial treatment and clinical outcome
CONDITIONS
Official Title
Antimicrobial Combination Therapy for Treatment of Enterococcus Faecalis Bacteremia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult (≥18 years)
- Diagnosis of monomicrobial Enterococcus faecalis bloodstream infection
- Received at least 5 days of one or more in vitro active antibiotics (such as ampicillin, amoxicillin/clavulanate, ampicillin/sulbactam, piperacillin, vancomycin, teicoplanin, daptomycin, or linezolid) with or without a synergistic drug (ceftriaxone, gentamycin, streptomycin) at standard doses
- Provided written informed consent
You will not qualify if you...
- Death within 3 days of bloodstream infection diagnosis
- Presence of other simultaneous infections
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Ospedale Maggiore "Carlo Alberto Pizzardi" di Bologna
Bologna, Bologna, Italy, 40133
Actively Recruiting
2
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Bologna, Italy, 40138
Actively Recruiting
3
Azienda Ospedaliero Universitaria di Catanzaro "Mater Domini"
Catanzaro, Catanzaro, Italy, 88100
Actively Recruiting
4
Humanitas Research Hospital
Milan, Milano, Italy, 20089
Actively Recruiting
Research Team
M
Maddalena Giannella, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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