Antimicrobial Efficacy of Nano-Based Intracanal Medications on Enterococcus Faecalis

What this Trial Is About

This research aims to evaluate the antimicrobial effects of new nano-based intracanal medications on reducing Enterococcus faecalis bacteria in patients with secondary endodontic infections. It focuses on cases where root canal treatments have failed due to persistent bacteria, particularly E. faecalis, which is common in infected root canals and known for its resistance and ability to survive harsh conditions. The study explores advanced treatment options using nanotechnology to improve disinfection outcomes in endodontic retreatment. The study compares three types of intracanal medications applied in retreatment cases: standard chlorohexidine gel, chlorohexidine loaded with silver nanoparticles gel, and triple antibiotic-loaded chitosan nanoparticles gel. These nano-formulated medications aim to enhance bacterial killing by leveraging the properties of nanoparticles. Participants receive one of these treatments applied inside the root canal to target the infection. Participants will undergo root canal retreatment on single-rooted premolar teeth with signs of infection. Samples from the root canal will be collected one week after medication application to measure the amount of Enterococcus faecalis bacteria. Researchers will also monitor post-operative pain during this period. The study uses bacterial cultures and clinical assessments to evaluate treatment effects and safety over a one-week follow-up, with total participation lasting about that time.

Antimicrobial Efficacy of Nano-Based ICM on E.F