Testing Antimicrobial Photodynamic Therapy Using Indocyanine Green Nanoparticles for Treating Stage III Periodontitis in Adults Aged 36 to 50

What this Trial Is About

Researchers are investigating new ways to treat generalized stage III periodontitis, a severe gum disease, by comparing different methods of antimicrobial photodynamic therapy aPDT. This study evaluates whether delivering a light-activated dye called indocyanine green ICG inside tiny biodegradable nanoparticles can better target harmful bacteria than using the dye alone or standard deep cleaning. The goal is to find a more effective, non-surgical treatment approach to protect teeth and gums. Participants are randomly assigned to one of three groups one receives non-surgical periodontal therapy followed by aPDT with ICG-loaded nanoparticles another receives the same therapy with ICG gel alone and aPDT and the last group receives only the non-surgical periodontal therapy. The light activation uses a specific diode laser applied to treated sites after dye application. All participants receive detailed oral hygiene instructions. Treatments and assessments occur over a 6-month period. During the study, clinical measures such as plaque, gingival health, probing depth, and attachment loss are recorded at baseline, 3 months, and 6 months. Samples of gum fluid are collected to analyze bacterial levels before, immediately after, and up to one month post-treatment. Participants undergo clinical and microbiological evaluations to assess the treatment effects. The trial includes safety monitoring and statistical analysis of results over the entire study duration.

Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management