Evaluating Diclofenac Sodium Compared to Calcium Hydroxide as Root Canal Medication for Treating Chronic Apical Periodontitis in Permanent Molars

What this Trial Is About

This research aims to evaluate the antibacterial effects of diclofenac sodium compared to calcium hydroxide paste when used as intracanal medications in permanent molar teeth affected by chronic apical periodontitis. The study focuses on whether diclofenac sodium, a type of nonsteroidal anti-inflammatory drug NSAID, can effectively reduce bacteria similarly to calcium hydroxide during primary root canal treatment. Participants will be randomly assigned to one of three groups to receive different intracanal medications. The study involves three groups one receiving a high concentration of diclofenac sodium mixed with saline, another receiving a low concentration mixed with saline, and a third group treated with calcium hydroxide paste. After cleaning and shaping the root canals, the assigned intracanal medication is placed and left inside the canal for one week. This treatment phase is followed by further evaluation and monitoring. Participants will have samples taken from their root canals before and after the medication placement to measure bacterial levels. Researchers will also assess healing of the periapical area via radiographic examination six months after treatment, monitor pain intensity using a visual scale at 24, 48, and 72 hours post-treatment, and record any flare-ups daily until the next visit after seven days. The main outcome measured is the bacterial count seven days after medication placement. The total study period includes follow-up assessments to evaluate treatment effects and safety.

The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament