Actively Recruiting
AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia
Led by University of Manitoba · Updated on 2026-04-21
4000
Participants Needed
64
Research Sites
285 weeks
Total Duration
On this page
Sponsors
U
University of Manitoba
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is an international, open-label, stratified randomized controlled trial with Bayesian adaptive stopping rules to compare the effects of therapeutic-dose heparin vs. usual care pharmacological thromboprophylaxis on outcomes in patients admitted to hospital with community acquired pneumonia (CAP).
CONDITIONS
Official Title
AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years of age or older
- Hospitalized for suspected or confirmed community-acquired pneumonia
- Radiographic evidence of new or worsening lung infiltrate
- At least one symptom or sign of lower respiratory infection (new or increased cough, sputum, fever, or abnormal white blood cell count)
- Primary diagnosis believed to be community-acquired pneumonia by attending physician
- Requires supplemental oxygen for low blood oxygen or increased oxygen if on chronic oxygen therapy
- Hospital admission expected to last at least 72 hours from randomization
You will not qualify if you...
- Suspected or confirmed active COVID-19 infection
- Hospitalized for more than 72 hours before randomization
- Receiving non-invasive or invasive ventilation, vasopressors, or extracorporeal life support in ICU at enrollment
- Requires chronic mechanical ventilation via tracheostomy before hospitalization
- Intention not to use pharmacologic thromboprophylaxis
- Has an independent reason for therapeutic-dose anticoagulation
- Contraindications to therapeutic-dose anticoagulation including recent non-traumatic bleeding, bleeding disorders, cerebral aneurysm or brain mass, recent ischemic stroke or gastrointestinal bleeding, low platelet count, high INR, low hemoglobin, or other physician concerns
- History of heparin-induced thrombocytopenia or heparin allergy
- Current or recent use of dual anti-platelet therapy within 7 days
- Imminent expected death
- Planned transfer to a non-study hospital within 72 hours
- Participation in other trials involving anticoagulation or antiplatelet therapy during current hospitalization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 64 locations
1
University of Chicago
Chicago, Illinois, United States, 60637
Not Yet Recruiting
2
Ochsner Clinic
Jefferson, Louisiana, United States, 70121
Actively Recruiting
3
Maine Medical Centre
Portland, Maine, United States, 04102
Actively Recruiting
4
Henry Ford Health System
Dearborn, Michigan, United States, 48128
Completed
5
Cooper University Health Care
Camden, New Jersey, United States, 08103
Actively Recruiting
6
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
7
Hospital Estadual Dr. Jayme Santos Neves
Serra, Espírito Santo, Brazil, 29166-828
Actively Recruiting
8
Hospital Evangelico de Vila Velha
Vila Velha, Espírito Santo, Brazil
Actively Recruiting
9
Hospital Universitário Cassiano Antonio Moraes
Vitória, Espírito Santo, Brazil
Not Yet Recruiting
10
Santa Casa de Misericordia de Itabuna
Itabuna, Estado de Bahia, Brazil
Completed
11
Hospital Brasilia
Brasília, Federal District, Brazil
Completed
12
Hospital Sao Brasilia
Brasília, Federal District, Brazil
Not Yet Recruiting
13
Instituto de Cardiologia e Transplantes do Distrito Federal
Brasília, Federal District, Brazil
Actively Recruiting
14
Hospital de Messejana Dr. Carlos Alberto Studart Gomes
Goiânia, Goiás, Brazil
Actively Recruiting
15
Hospital Ruy Azeredo
Goiânia, Goiás, Brazil
Actively Recruiting
16
Instituto Goiano de Oncologia e Hematologia - INGOH
Goiânia, Goiás, Brazil
Actively Recruiting
17
Hospital Felicio Rocho
Belo Horizonte, Minas Gerais, Brazil
Actively Recruiting
18
NUPEC-Orizonti
Belo Horizonte, Minas Gerais, Brazil
Completed
19
Hospital do Rocio
Campo Largo, Paraná, Brazil, 83606-177
Actively Recruiting
20
Hospital Santa Cruz
Curitiba, Paraná, Brazil
Actively Recruiting
21
PUCPR
Curitiba, Paraná, Brazil
Completed
22
Hospital Bruno Born
Lajeado, Rio Grande do Sul, Brazil
Actively Recruiting
23
Hospital Sao Vicente de Paulo
Passo Fundo, Rio Grande do Sul, Brazil
Actively Recruiting
24
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil
Actively Recruiting
25
Hospital Universitario de Santa Maria
Santa Maria, Rio Grande do Sul, Brazil
Actively Recruiting
26
Hospital Sao Jose
Criciúma, Santa Catarina, Brazil
Actively Recruiting
27
Hospital Regional Homero Miranda Gomes
São José, South Carolina, Brazil
Completed
28
Hospital de Reabilitacao de Anomalias Craniofaciais
Bauru, São Paulo, Brazil
Not Yet Recruiting
29
UPECLIN - Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu
Botucatu, São Paulo, Brazil
Actively Recruiting
30
Hospital Universitario Sao Francisco na Providencia na Deus
Bragança Paulista, São Paulo, Brazil
Actively Recruiting
31
Fundação Centro Médico de Campinas
Campinas, São Paulo, Brazil, 13083-190
Actively Recruiting
32
IPECC
Campinas, São Paulo, Brazil
Actively Recruiting
33
CiTen - Centro Hospital Municipal Antonio Giglio
Osasco, São Paulo, Brazil
Actively Recruiting
34
Hospital Regional de Presidente Prudente
Presidente Prudente, São Paulo, Brazil
Actively Recruiting
35
Hospital Estadual de Serrana
Ribeirão Preto, São Paulo, Brazil
Not Yet Recruiting
36
Hospital Nipo-Brasileiro
São Paulo, São Paulo, Brazil, 02189-010
Actively Recruiting
37
HCFMUSP
São Paulo, São Paulo, Brazil, 05403-010
Actively Recruiting
38
Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo
São Paulo, São Paulo, Brazil
Not Yet Recruiting
39
Santa Casa de Misericordia de Sao Paulo
São Paulo, São Paulo, Brazil
Actively Recruiting
40
Foothills Medical Centre
Calgary, Alberta, Canada, T2N 2T9
Actively Recruiting
41
Grand Prairie Regional Hospital
Grande Prairie, Alberta, Canada, T8V 4B1
Not Yet Recruiting
42
Nanaimo Regional General Hospital
Nanaimo, British Columbia, Canada
Actively Recruiting
43
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9
Actively Recruiting
44
Health Sciences Center Winnipeg
Winnipeg, Manitoba, Canada, R3A 1R9
Actively Recruiting
45
Grace General Hospital
Winnipeg, Manitoba, Canada
Actively Recruiting
46
St. Boniface General Hospital
Winnipeg, Manitoba, Canada
Actively Recruiting
47
Memorial University
St. John's, Newfoundland and Labrador, Canada, A1C 5S7
Actively Recruiting
48
Health Sciences North Research Institute
Greater Sudbury, Ontario, Canada, P3E 2H3
Actively Recruiting
49
Hamilton Health Sciences - Juravinski
Hamilton, Ontario, Canada
Actively Recruiting
50
Hamilton Health Sciences
Hamilton, Ontario, Canada
Actively Recruiting
51
Markham Stouffville Hospital
Markham, Ontario, Canada, L3P 7P3
Actively Recruiting
52
Hôpital Montfort
Ottawa, Ontario, Canada
Actively Recruiting
53
The Ottawa Hospital
Ottawa, Ontario, Canada
Actively Recruiting
54
Niagara Health System - St Catharines Site
Saint Catherines, Ontario, Canada, L2S 0A9
Actively Recruiting
55
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
56
University Health Network
Toronto, Ontario, Canada, M5G2C4
Not Yet Recruiting
57
Centre Hospitalier de Quebec - Hotel-Dieu de Levis
Lévis, Quebec, Canada, G6V 3Z1
Not Yet Recruiting
58
McGill University Health Centre
Montreal, Quebec, Canada, H4A3J1
Actively Recruiting
59
Centre Hospitalier de l'université de Montréal (CHUM)
Montreal, Quebec, Canada
Actively Recruiting
60
Jewish General Hospital
Montreal, Quebec, Canada
Actively Recruiting
61
CHU de Quebec-University Laval
Québec, Quebec, Canada
Actively Recruiting
62
Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)
Québec, Quebec, Canada
Actively Recruiting
63
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, Canada
Actively Recruiting
64
Regina General Hospital
Regina, Saskatchewan, Canada, S4P 0W5
Actively Recruiting
Research Team
C
Chantale Pineau
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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