Actively Recruiting
Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD Clinical Trial
Led by Mount Sinai Hospital, Canada · Updated on 2025-01-24
118
Participants Needed
4
Research Sites
104 weeks
Total Duration
On this page
Sponsors
M
Mount Sinai Hospital, Canada
Lead Sponsor
U
Unity Health Toronto
Collaborating Sponsor
AI-Summary
What this Trial Is About
The DEFEND trial will be the world's first clinical trial to study the effectiveness of Paxlovid or Veklury in the prevention of cardiovascular post-acute sequelae of SARS-CoV-2 among hospitalized adults. Additionally, this pilot study will inform the design and conduct of a future full-scale multi-centre trial by testing the feasibility and accuracy of this study design.
CONDITIONS
Official Title
Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years old or older
- Positive PCR test for SARS-CoV-2 within 5 days of hospital admission
- Normoxic (not receiving supplemental oxygen)
- Able to provide informed written consent or have a substitute decision maker available
You will not qualify if you...
- Severe allergy to Paxlovid or Veklury (e.g., anaphylaxis)
- Taking drugs highly dependent on CYP3A for clearance or potent CYP3A inducers
- Received Paxlovid or Veklury within the previous 14 days
- Receiving supplemental oxygen
- Positive SARS-CoV-2 test 5 to 90 days before hospital admission
- Life expectancy of 3 months or less
- Pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Kingston Health Sciences Centre
Kingston, Ontario, Canada, K7L 2V7
Not Yet Recruiting
2
Niagara Health System
St. Catharines, Ontario, Canada, L2S 0A9
Not Yet Recruiting
3
Mount Sinai Hospital, Sinai Health System
Toronto, Ontario, Canada, M5G 1X5
Actively Recruiting
4
St. Joseph's Health Centre, Unity Health Toronto
Toronto, Ontario, Canada, M6R 1B5
Not Yet Recruiting
Research Team
D
Dr. Kieran Quinn
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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