Actively Recruiting
Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
Led by Amgen · Updated on 2026-04-13
500
Participants Needed
83
Research Sites
370 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor Anvumetostat administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted thoracic tumors. The study also aims to determine the safety profile of Anvumetostat administered in combination with other therapies in adult participants with metastatic or locally advanced MTAP-deleted thoracic tumors.
CONDITIONS
Official Title
Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older (or legal adult age if higher in country)
- Available tumor tissue sample or willingness to undergo biopsy before treatment
- Confirmed homozygous MTAP deletion in tumor
- Able to swallow and retain oral study medication
- Disease measurable by RECIST v1.1 criteria
- For Subprotocol A: confirmed diagnosis of non-small cell lung cancer (NSCLC)
- For Arm A: predominantly squamous cell histology
- For Arm B: predominantly non-squamous cell histology
- For Arm C: PD-L1 positive tumors
- For Subprotocol B: NSCLC with homozygous MTAP deletion and KRAS p.G12C mutation
- For Subprotocol C: NSCLC with brain metastases meeting measurable disease criteria
You will not qualify if you...
- Cardiovascular and pulmonary conditions as detailed in the protocol
- Gastrointestinal diseases causing inability to take oral medication or malabsorption
- History of solid organ transplant
- Major surgery within 28 days before first dose
- Prior treatment with MAT2A or PRMT5 inhibitors
- Radiation therapy within 28 days before first dose
- For Subprotocol A: autoimmune or immunodeficiency diseases as defined in the protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 83 locations
1
Comprehensive Blood and Cancer Center
Bakersfield, California, United States, 93309
Actively Recruiting
2
City of Hope National Medical Center
Duarte, California, United States, 91010
Terminated
3
City of Hope Orange County Lennar Foundation Cancer Center
Duarte, California, United States, 91010
Terminated
4
Translational Research in Oncology US Inc, Trio Central Pharmacy
Los Angeles, California, United States, 90095
Actively Recruiting
5
University of California Irvine
Orange, California, United States, 92868-3217
Actively Recruiting
6
University of California Los Angeles
Santa Monica, California, United States, 90404
Actively Recruiting
7
Rocky Mountain Cancer Centers
Denver, Colorado, United States, 80218
Actively Recruiting
8
Eastern Connecticut Hematology and Oncology Associates
Norwich, Connecticut, United States, 06360
Terminated
9
HealthPartners Institute
Saint Paul, Minnesota, United States, 55102
Actively Recruiting
10
Saint Lukes Hospital of Kansas City
Kansas City, Missouri, United States, 64111
Terminated
11
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, United States, 89169
Terminated
12
Roswell Park Cancer Institute
Buffalo, New York, United States, 32224
Actively Recruiting
13
New York University Grossman School of Medicine
New York, New York, United States, 10016
Actively Recruiting
14
Perlmutter Cancer Center at New York University Langone Hospital----Long Island
New York, New York, United States, 10016
Actively Recruiting
15
Upstate University Hospital
Syracuse, New York, United States, 13210
Actively Recruiting
16
Hightower Clinical
Oklahoma City, Oklahoma, United States, 73102
Actively Recruiting
17
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111
Actively Recruiting
18
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
19
University of Tennessee Medical Center Knoxville
Knoxville, Tennessee, United States, 37920
Actively Recruiting
20
United States Oncology Regulatory Affairs Corporate Office
Nashville, Tennessee, United States, 37203
Actively Recruiting
21
Texas Oncology - Dallas Fort Worth
Dallas, Texas, United States, 75246
Terminated
22
US Oncology Research Investigational Products Center
Dallas, Texas, United States, 75246
Actively Recruiting
23
Oncology Consultants Cancer Center
Houston, Texas, United States, 77030
Terminated
24
Texas Oncology Northeast Texas
Tyler, Texas, United States, 75702
Actively Recruiting
25
Virginia Cancer Specialists PC
Fairfax, Virginia, United States, 22031
Actively Recruiting
26
Northwest Medical Specialties, PLLC
Tacoma, Washington, United States, 98405
Actively Recruiting
27
Instituto Argentino de Diagnóstico y Tratamiento
Ciudad Automona de Buenos Aires, Buenos Aires, Argentina, C1117ABC
Actively Recruiting
28
Hospital Universitario Austral
Pilar, Buenos Aires, Argentina, B1629ODT
Actively Recruiting
29
Cemic
Ciudad Autonoma Buenos Aires, Argentina, C1431FWO
Actively Recruiting
30
Orange Health Service
Orange, New South Wales, Australia, 2800
Actively Recruiting
31
The Queen Elizabeth Hospital
Woodville South, South Australia, Australia, 5011
Actively Recruiting
32
Medizinische Universitaet Graz
Graz, Austria, 8036
Actively Recruiting
33
Medizinische Universitaet Innsbruck
Innsbruck, Austria, 6020
Actively Recruiting
34
Centre Hospitalier Universitaire de Liege - Sart Tilman
Liège, Belgium, 4000
Actively Recruiting
35
Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda
Ijuí, Rio Grande do Sul, Brazil, 98700-000
Actively Recruiting
36
Cipo - Centro Integrado de Pesquisa em Oncologia
Porto Alegre, Rio Grande do Sul, Brazil, 91350-200
Actively Recruiting
37
Fund Faculdade Regional Med Sao Jose Rio Preto
São José do Rio Preto, São Paulo, Brazil, 15090-000
Actively Recruiting
38
Beneficencia Portuguesa de Sao Paulo - Bp
São Paulo, São Paulo, Brazil, 01509-900
Actively Recruiting
39
Instituto Cancer Sao Paulo Icesp
São Paulo, Brazil, 01246-000
Actively Recruiting
40
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
41
Mengchao Hepatobiliary Hospital of Fujian Medical University
Fuzhou, Fujian, China, 350028
Actively Recruiting
42
Guangdong Provincial Peoples Hospital
Guangzhou, Guangdong, China, 510000
Actively Recruiting
43
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
Actively Recruiting
44
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, China, 430022
Actively Recruiting
45
Jilin Cancer Hospital
Changchun, Jilin, China, 130012
Actively Recruiting
46
West China Hospital Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
47
Beijing Cancer Hospital
Beijing, China, 100142
Actively Recruiting
48
Institut Bergonie
Bordeaux, France, 33000
Actively Recruiting
49
Hopital de la Timone
Marseille, France, 13005
Actively Recruiting
50
Institut de Cancerologie de l Ouest Rene Gauducheau
Saint-Herblain, France, 44805
Actively Recruiting
51
Gustave Roussy
Villejuif, France, 94805
Actively Recruiting
52
Universitaetsklinikum Essen
Essen, Germany, 45147
Actively Recruiting
53
Universitaetsklinikum Heidelberg
Heidelberg, Germany, 69126
Actively Recruiting
54
Universitaetsklinikum Wuerzburg
Würzburg, Germany, 97078
Actively Recruiting
55
Alexandra Hospital
Athens, Greece, 11528
Actively Recruiting
56
General Hospital Of Thessaloniki Papageorgiou
Thessaloniki, Greece, 56429
Actively Recruiting
57
European Interbalkan Medical Center
Thessaloniki, Greece, 57001
Actively Recruiting
58
Queen Mary Hospital, The University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
59
Prince of Wales Hospital, Chinese University of Hong Kong
Shatin, New Territories, Hong Kong
Actively Recruiting
60
Fondazione IRCCS Istituto Nazionale dei Tumori
Alessandria, Italy, 15100
Actively Recruiting
61
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, Italy, 20162
Actively Recruiting
62
IRCCS Istituto Clinico Humanitas
Rozzano (MI), Italy, 20089
Actively Recruiting
63
Centro Ricerche Cliniche Di Verona Societa responsabilita limitata
Verona, Italy, 37126
Actively Recruiting
64
Aichi Cancer Center
Nagoya, Aichi-ken, Japan, 464-8681
Actively Recruiting
65
National Cancer Center Hospital East
Kashiwa-shi, Chiba, Japan, 277-8577
Actively Recruiting
66
Shizuoka Cancer Center
Sunto-gun, Shizuoka, Japan, 411-8777
Actively Recruiting
67
Wakayama Medical University Hospital
Wakayama, Wakayama, Japan, 641-8510
Actively Recruiting
68
Radboud Universitair Medisch Centrum
Nijmegen, Netherlands, 6525 GA
Actively Recruiting
69
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland, 80-214
Actively Recruiting
70
Narodowy Instytut Onkologii im Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
Gliwice, Poland, 44-102
Actively Recruiting
71
Futuremeds spolka z ograniczona odpowiedzialnoscia
Krakow, Poland, 31-501
Actively Recruiting
72
Instytut Centrum Zdrowia Matki Polki
Lodz, Poland, 93-338
Actively Recruiting
73
Centrum Medyczne Hope Clinic Sebastian Szklener
Lublin, Poland, 20-701
Actively Recruiting
74
Seoul National University Hospital
Seoul, South Korea, 03080
Actively Recruiting
75
Asan Medical Center
Seoul, South Korea, 05505
Actively Recruiting
76
Hospital Universitari Vall d Hebron
Barcelona, Catalonia, Spain, 08035
Actively Recruiting
77
Hospital Clinic i Provincial de Barcelona
Barcelona, Catalonia, Spain, 08036
Actively Recruiting
78
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
79
National Cheng Kung University Hospital
Tainan, Taiwan, 70403
Actively Recruiting
80
Taipei Veterans General Hospital
Taipei, Taiwan, 11217
Actively Recruiting
81
Adana Sehir Egitim ve Arastirma Hastanesi
Adana, Turkey (Türkiye), 01370
Actively Recruiting
82
Hacettepe Universitesi Tip Fakultesi Hastanesi
Ankara, Turkey (Türkiye), 06230
Actively Recruiting
83
Ankara Bilkent Sehir Hastanesi
Ankara, Turkey (Türkiye), 06800
Actively Recruiting
Research Team
A
Amgen Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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