Actively Recruiting
Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG
Led by China National Center for Cardiovascular Diseases · Updated on 2026-04-14
380
Participants Needed
4
Research Sites
120 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To explore surgical strategies that reduce perioperative neurologic complications in cardiovascular surgery, with the aim of improving perioperative outcomes and quality of life while reducing the socioeconomic burden. Specifically: This multicenter, randomized controlled clinical trial will evaluate the benefits of a novel aortic no-touch technique in reducing perioperative silent brain infarction(SBI) among patients undergoing surgical treatment for coronary artery disease. The findings are expected to provide a safe and effective myocardial revascularization strategy for individuals at high risk of cerebral ischemia.
CONDITIONS
Official Title
Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (>18 years old) with multivessel coronary artery disease scheduled for isolated off-pump coronary artery bypass grafting
- Must provide informed consent to participate in the study
You will not qualify if you...
- Need for cardiopulmonary bypass surgery or no contraindication to on-pump surgery
- Unsuitable great saphenous vein for grafting
- Subclavian artery stenosis or occlusion, or contraindication to using the internal mammary artery as a graft
- History of previous cardiac surgery
- Emergency surgery cases
- Inability to apply aortic clamp due to severe ascending aortic calcification
- Expected inability to tolerate MRI or contraindications to MRI such as implanted permanent pacemaker
- Inability to complete neurocognitive assessment due to language barriers or visual/hearing impairment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 4 locations
1
Fuwai Hospital Chinese Academy of Medical Sciences
Beijing, China
Actively Recruiting
2
Peking University First Hospita
Beijing, China
Not Yet Recruiting
3
Qingdao Cardiovascular Hospital
Qingdao, China
Not Yet Recruiting
4
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
Shenzhen, China
Not Yet Recruiting
Research Team
L
Lianxin Chen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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