Comparing Aortic No-Touch and Partial Clamping Techniques in Off-Pump Coronary Artery Bypass Surgery to Reduce Brain Complications

What this Trial Is About

Researchers are evaluating surgical approaches to reduce brain-related complications during coronary artery bypass grafting CABG in patients with coronary artery disease. This multicenter, randomized controlled trial aims to improve outcomes and quality of life by comparing a new aortic no-touch technique with the conventional partial clamping method. The study focuses on lowering silent brain infarction and other neurological risks during surgery. The trial compares two surgical methods for off-pump CABG one uses a partial clamp on the ascending aorta to connect the saphenous vein graft, while the other avoids any aortic manipulation by attaching the vein graft to the right internal mammary artery as a composite graft. These two approaches will be assessed for safety and effectiveness in preventing brain injury and other cardiovascular events. Participants will undergo surgery followed by detailed assessments including neurocognitive tests and MRI scans within the first week after surgery to detect brain infarcts or strokes. Researchers will monitor outcomes such as graft blockage, cognitive function, delirium, and major cardiac or cerebrovascular events for up to one year. Safety and quality of life measures will be evaluated throughout the study period to understand the impact of each surgical strategy.

Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG