Actively Recruiting
AOrtic Surgery: Systemic Inflammatory Response Versus Sepsis
Led by University Hospital Hradec Kralove · Updated on 2024-05-21
60
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
Sponsors
U
University Hospital Hradec Kralove
Lead Sponsor
A
American Association for Thoracic Surgery
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of the prospective observational study is to evaluate the immunological background of inflammatory response often seen after open thoracic aortic surgery. Patients scheduled for this type of procedure will undergo a series of blood testing (preoperatively, and several times postoperatively). The blood samples will be used for a wide scale of immunological tests to better evaluate potential differential markers against infection. A control group will include patients with active infective endocarditis (preoperatively). The main question is if there is a biomarker able to determine a difference between sterile systemic inflammation and infection after thoracic aortic surgery. The second question is if there is a difference in dynamics of evaluated biomarkers between sterile postoperative inflammation and active endocarditis.
CONDITIONS
Official Title
AOrtic Surgery: Systemic Inflammatory Response Versus Sepsis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient scheduled for elective replacement of thoracic aorta of any extent by artificial vascular graft, including Bentall procedure, Yacoub procedure, supracoronary aortic replacement, Ross procedure with supracoronary aortic replacement, hemiarch and total aortic arch replacement
- Signed informed patient consent (study group)
- Patient with active infectious endocarditis (control group)
- Signed informed patient consent (control group)
You will not qualify if you...
- Active endocarditis or other infection (study group)
- Unstable preoperative condition (study group)
- More than 5 days since diagnosis of infectious endocarditis (control group)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Hradec Králové
Hradec Králové, Královehradecký Kraj, Czechia, 500 02
Actively Recruiting
Research Team
J
Jan Gofus, MD, PhD
CONTACT
A
Andrej Myjavec, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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