Actively Recruiting

Age: 18Years - 65Years
All Genders
NCT03768271

APACHE Cohort (A Psoriatic Arthritis CoHort)

Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-04-27

425

Participants Needed

3

Research Sites

876 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Psoriatic arthritis (PsA) is a chronic inflammatory rheumatic disease, belonging to the wide spectrum of spondyloarthritis, but with the particularity to be associated with personal psoriasis or familial psoriasis. PsA can be a very disabling disease through progressive and irreversible joint damage. Long-term functional prognosis of patients with PsA is correlated with the presence and severity of the radiographic joint lesions of the disease. However, the proportion of patients who will develop those peripheral joint damages is not yet known and less over the factors which are associated/involved in such an aggressive pattern of the disease. Early identification of this subgroup of patients is particularly important for determining early "intensive" treatment, strict management with a Treat To Target approach, and identification of new treatments with a stronger structural effect. The main objective of this prospective 10 years cohort is to describe the 5 years structural (radiographic) severity of recent Psoriatic arthritis (PsA)with recent peripheral arthritis.Some of the secondary objectives are to describe the 10 years structural severity within those patients, and to determine the predictive factors of those 5 and 10 years radiographic lesions (genetic, environmental, clinic, therapeutic factors). APACHE will provide a unique longitudinal standardized database concerning patients with PsA with very recent peripheral arthritis. Research projects which will based on those collected data should allow to identify the mechanisms of aggressive joint damage, to highlight mew treatments targets, to better describe the burden of the disease, to test previous or develop new assessments tolls, to develop early diagnostic criteria

CONDITIONS

Official Title

APACHE Cohort (A Psoriatic Arthritis CoHort)

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Women or men aged from 18 to 65 inclusive
  • First episode of peripheral arthritis in the last 12 months, confirmed by a rheumatologist
  • Diagnosis of psoriasis by a practitioner or family history of psoriatic arthritis (first- or second-degree relative)
  • Arthritis likely recognized as psoriatic arthritis by a rheumatologist with diagnostic confidence score of 7 or higher out of 10
  • Signed informed consent form
  • Affiliated with a social security system
Not Eligible

You will not qualify if you...

  • Diagnosed with inflammatory rheumatism other than psoriatic arthritis
  • Current or past treatment with biomedicine
  • Received csDMARDS (methotrexate, sulfasalazine, or leflunomide) or apremilast treatment in the past year for rheumatological symptoms
  • Used oral steroids above 10 mg/day prednisone or with changed dosage in the last 4 weeks
  • Received intravenous or intra-articular steroids in the last 4 weeks
  • Contraindication to MRI
  • Cognitive, mental, or psychiatric disorders preventing protocol compliance
  • Difficulties understanding French
  • Under tutorship or curatorship
  • Pregnant

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 3 locations

1

Henri-Mondor Hospital

Créteil, France, 94000

Actively Recruiting

2

Lapeyronie Hospital

Montpellier, France, 34090

Actively Recruiting

3

Saint Joseph Hospital

Paris, France, 75014

Actively Recruiting

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Research Team

P

Pascal CLAUDEPIERRE, PHD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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