Actively Recruiting
APACHE Cohort (A Psoriatic Arthritis CoHort)
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-04-27
425
Participants Needed
3
Research Sites
876 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Psoriatic arthritis (PsA) is a chronic inflammatory rheumatic disease, belonging to the wide spectrum of spondyloarthritis, but with the particularity to be associated with personal psoriasis or familial psoriasis. PsA can be a very disabling disease through progressive and irreversible joint damage. Long-term functional prognosis of patients with PsA is correlated with the presence and severity of the radiographic joint lesions of the disease. However, the proportion of patients who will develop those peripheral joint damages is not yet known and less over the factors which are associated/involved in such an aggressive pattern of the disease. Early identification of this subgroup of patients is particularly important for determining early "intensive" treatment, strict management with a Treat To Target approach, and identification of new treatments with a stronger structural effect. The main objective of this prospective 10 years cohort is to describe the 5 years structural (radiographic) severity of recent Psoriatic arthritis (PsA)with recent peripheral arthritis.Some of the secondary objectives are to describe the 10 years structural severity within those patients, and to determine the predictive factors of those 5 and 10 years radiographic lesions (genetic, environmental, clinic, therapeutic factors). APACHE will provide a unique longitudinal standardized database concerning patients with PsA with very recent peripheral arthritis. Research projects which will based on those collected data should allow to identify the mechanisms of aggressive joint damage, to highlight mew treatments targets, to better describe the burden of the disease, to test previous or develop new assessments tolls, to develop early diagnostic criteria
CONDITIONS
Official Title
APACHE Cohort (A Psoriatic Arthritis CoHort)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women or men aged from 18 to 65 inclusive
- First episode of peripheral arthritis in the last 12 months, confirmed by a rheumatologist
- Diagnosis of psoriasis by a practitioner or family history of psoriatic arthritis (first- or second-degree relative)
- Arthritis likely recognized as psoriatic arthritis by a rheumatologist with diagnostic confidence score of 7 or higher out of 10
- Signed informed consent form
- Affiliated with a social security system
You will not qualify if you...
- Diagnosed with inflammatory rheumatism other than psoriatic arthritis
- Current or past treatment with biomedicine
- Received csDMARDS (methotrexate, sulfasalazine, or leflunomide) or apremilast treatment in the past year for rheumatological symptoms
- Used oral steroids above 10 mg/day prednisone or with changed dosage in the last 4 weeks
- Received intravenous or intra-articular steroids in the last 4 weeks
- Contraindication to MRI
- Cognitive, mental, or psychiatric disorders preventing protocol compliance
- Difficulties understanding French
- Under tutorship or curatorship
- Pregnant
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Henri-Mondor Hospital
Créteil, France, 94000
Actively Recruiting
2
Lapeyronie Hospital
Montpellier, France, 34090
Actively Recruiting
3
Saint Joseph Hospital
Paris, France, 75014
Actively Recruiting
Research Team
P
Pascal CLAUDEPIERRE, PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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