French Cohort on the Becoming of Recent Articular Psoriatic Rheumatism (A Psoriatic Arthritis CoHort)

What this Trial Is About

Psoriatic arthritis (PsA) is a chronic inflammatory disease that can cause progressive and irreversible joint damage, often linked to personal or family history of psoriasis. This research aims to follow patients with recent peripheral arthritis attributed to PsA to describe the severity of joint damage over 5 and 10 years and identify factors like genetic, environmental, clinical, and treatment-related influences that predict this damage. The study will create a unique long-term database to better understand the disease and guide new treatment targets and assessments. This is a prospective national study involving 425 patients across 30 centers, followed for 10 years after experiencing their first episode of peripheral arthritis within the past year. Standardized visits will collect clinical information, patient-reported outcomes, lab tests, and samples including plasma, serum, urine, RNA, and DNA. Imaging assessments such as X-rays, ultrasounds, and MRI will be performed at different times. No treatment decisions will be made during these visits as it is an observational study. Participants will attend regular scheduled visits over the 10-year period where various clinical and laboratory data will be gathered. Researchers will monitor joint damage through X-rays at 5 and 10 years, assessing erosions, joint space narrowing, and periostitic lesions. The study will also collect patient-reported outcomes and biological samples to support multiple research projects. Participation requires informed consent and affiliation to a social security system, with safety and language ability monitored throughout.

APACHE Cohort (A Psoriatic Arthritis CoHort)