Actively Recruiting
Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept
Led by Hospital Center Guillaume Régnier · Updated on 2025-04-06
30
Participants Needed
1
Research Sites
235 weeks
Total Duration
On this page
Sponsors
H
Hospital Center Guillaume Régnier
Lead Sponsor
R
Rennes University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to identify reliable markers of apathy in elderly subjects with bipolar disorder, age between 70 and 85 years, in order to accurately identify subjects at high risk of progressing to dementia by measuring motor activity (actimetrics), recorded language and analysing brain changes (MRI). Actimetry is the measurement and recording of body movements using an actimeter. This device is worn on the wrist and contains sensors capable of measuring and recording all movements, including those of very low intensity. An automated speech analysis using artificial intelligence is used to detect low-intensity anomalies, and we want to test whether individual differences correspond to individual differences in brain anatomy and function. Researchers will compare elderly subjects with bipolar disorder and healthy volunteer, age between 70 and 85 years. Participants will be asked to: * Perform an MRI * Complete 3 cognitive tests: verbal memory, verbal fluency and an emotional storytelling task, in which you will be asked to describe a memory orally using positive, negative and neutral emotions. * wear an actimeter on your wrist for 4 days.
CONDITIONS
Official Title
Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 70 and 85 years old, living at home
- Diagnosed with bipolar disorder type 1, 2, or 3 according to DSM5 criteria
- Stable condition with no major depressive episode or hypomanic state in the last 6 months
- Ambulatory and able to participate in outpatient setting
- Able to walk 4 meters in 4 seconds or less as measured by the Short Physical Performance Battery (SPPB)
- Affiliated with a social security regime
- Provided free, informed, and written consent to participate
You will not qualify if you...
- History of unipolar depression or recurrent unipolar depression
- Substance use disorder, except dependence on benzodiazepines or z-drugs
- Major cognitive disorder with significant decline and loss of autonomy unrelated to delirium
- Medical history of degenerative brain disorders such as Alzheimer's disease, fronto-temporal disorders, Lewy Body disease, corticobasal degeneration, supranuclear palsy, or epilepsy
- Medical history of Parkinson's disease or severe parkinsonism
- History of stroke
- Contraindications for MRI such as metallic implants or severe claustrophobia
- Adults under legal protection or deprived of liberty
- Hospitalized at time of inclusion
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Centre Hospitalier Guillaume Regnier
Rennes, Ile Et Vilaine, France, 35000
Actively Recruiting
Research Team
G
Gabriel RG ROBERT
CONTACT
N
Nathalie AN ALLETON
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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