Effect of Temporary Porto-caval Shunt on Liver Graft Function During Liver Transplantation Using Extended Criteria Donor Grafts

What this Trial Is About

Researchers are studying liver transplantation in patients with liver cancer or end-stage liver disease who receive grafts from extended criteria donors ECD. These donors have factors that increase the risk of complications like primary non-function or early graft dysfunction due to greater susceptibility to injury during transplantation. The study aims to evaluate whether using a temporary porto-caval shunt TPCS during the transplant surgery can reduce these risks by preventing blood congestion and inflammation in the gut. Participants are randomly assigned to one of two groups those who receive the temporary porto-caval shunt during the transplant surgery and those who do not. The shunt is created by connecting the portal vein to the vena cava during the phase when the liver is removed. This procedure is intended to reduce damage during the operation. The study measures outcomes such as early graft function and complications within the first week after surgery. During the study, researchers will monitor liver function and complications up to three months after transplantation. They will assess early allograft dysfunction and primary non-function within the first seven postoperative days, along with surgery duration, transfusions, reperfusion syndrome shortly after blood flow restoration, urinary function, and survival of both graft and patient. Participants will be followed closely during this time to evaluate the effects of the shunt on transplant outcomes.

APCext : Effect of Temporary Porto-caval Shunt During Liver Transplantation on Function of Liver Graft From Extended Criteria Donor