Actively Recruiting
Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-05-01
3000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will collect blood plasma and white blood cells from individuals using a procedure called apheresis. Apheresis is a method of collecting larger quantities of certain blood components that can safely be collected through a simple blood draw. The blood components will be used in laboratory research studies. Patients 18 years of age and older who are currently enrolled in a NIH clinical research protocol may participate in this study. Relatives of patients and normal healthy volunteers will also be enrolled. Individuals will undergo one of the following two apheresis procedures: * Automated pheresis Blood is drawn through a needle placed in an arm vein and circulated through a cell separator machine. The plasma (liquid part of the blood) and white cells are extracted, and the red cells are re-infused into the donor through the same needle or a needle in the other arm. An anticoagulant (medication to prevent blood from clotting) is usually added to the blood while in the machine to prevent it from clotting during processing. * Manual pheresis One unit (1 pint) of blood is drawn through a needle placed in an arm vein, similar to donating a pint of whole blood. The red blood cells, with or without plasma, are separated from the rest of the blood and returned to the donor through the same needle. Manual pheresis will be done only when a person s estimated total blood volume or red cell count is too low to safely permit removal of blood through a pheresis machine. An adult small in size or markedly anemic, for example, may fall into this category. Some of the blood collected through apheresis may be stored for future studies of HIV disease and immune function and for HLA testing, a genetic test of markers of the immune system. Some of the blood may be used to screen for different types of viral liver infections, such as hepatitis A, B, C, D, E, F, or G.
CONDITIONS
Official Title
Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Adequate venous access
- Blood pressure less than or equal to 180/100; pulse rate 50-100, or lower if normal for the volunteer
- Adequate blood counts if undergoing apheresis: for HIV positive or inflammatory disease volunteers, hemoglobin ≥ 9.0 g/dL, hematocrit ≥ 28%, platelets ≥ 50,000; for HIV negative volunteers, hemoglobin ≥ 12.5 g/dL, hematocrit ≥ 38%, platelets ≥ 150,000
- Willing and able to provide written informed consent and comply with study procedures including sample storage, hepatitis screening, and genetic testing
You will not qualify if you...
- Pregnant and/or breastfeeding women
- Current abuse of alcohol or other drugs
- Any medical condition that the principal investigator feels makes apheresis or sample collection unsafe
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
H
Holly A Baus, R.N.
CONTACT
S
Susan L Moir, Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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