Actively Recruiting
Apixaban Prophylaxis for Prevention of Left Ventricular Thrombus Following Anterior Myocardial Infarction
Led by National Institute of Cardiovascular Diseases, Pakistan · Updated on 2024-12-19
472
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this randomized controlled trial is to compare the safety and efficacy of low dose Apixaban (2.5 mg bid) in addition to guideline directed medical therapy vs guideline directed medical therapy alone in the prevention of left ventricular thrombus formation (after 30-days) following primary PCI in patients with acute anterior myocardial infarction with severe LV dysfunction.
CONDITIONS
Official Title
Apixaban Prophylaxis for Prevention of Left Ventricular Thrombus Following Anterior Myocardial Infarction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 65 years
- Diagnosed with acute anterior STEMI
- Severe left ventricular dysfunction with ejection fraction below 35%
- Presence of antero-apical akinesis, dyskinesis, or aneurysm
- No evidence of left ventricular thrombus
You will not qualify if you...
- Previous anterior myocardial infarction or LAD revascularization procedures
- Cardiogenic shock
- Existing left ventricular thrombus
- Advanced chronic kidney disease with creatinine over 2 or on hemodialysis
- Recent intracranial hemorrhage or major bleeding requiring transfusion
- Low platelet count below 100,000
- History of stroke within the past three months
- Atrial fibrillation or other reasons for ongoing anticoagulation
- Pregnancy or hematological disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
NICVD Pakistan
Karachi, Sindh, Pakistan
Actively Recruiting
Research Team
A
Abdul Hakeem, MD FACC FSCAI FASE
CONTACT
S
Sabha Bhatti, MD FASE FASNC FACC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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