Study of APOL1 Genetic Testing to Understand Kidney Disease Risk and Patient Attitudes in African American Adults

What this Trial Is About

Researchers are investigating the role of specific genetic variants in the APOL1 gene that increase the risk of kidney failure in Black Americans. This study focuses on understanding the frequency of these APOL1 renal risk variants and how knowledge of ones genetic status affects attitudes towards managing hypertension and kidney health. The study also explores environmental and genetic interactions that may influence kidney disease progression in this population. Participants will have one blood sample collected to determine their APOL1 genotype and will complete surveys about their beliefs and attitudes towards kidney disease, hypertension, diabetes, and genetic testing. Results are shared by phone, and follow-up surveys are conducted at 3 and 12 months to assess any changes in attitudes. Those found to have high-risk genotypes may speak with a genetic counselor if they wish. During the study, participants complete initial and follow-up surveys and provide genetic samples. Researchers measure the frequency of APOL1 risk variants among participants and their first-degree relatives. The study monitors participant responses over one year to understand how genetic information impacts health management. Participation ranges from initial enrollment through a year of follow-up assessments.

APOL1 Genetic Testing in African Americans