Actively Recruiting
Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain
Led by University of Washington · Updated on 2024-05-24
90
Participants Needed
1
Research Sites
243 weeks
Total Duration
On this page
Sponsors
U
University of Washington
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
High fat feeding (HFF) increases the risk of Alzheimer's disease (AD) but individuals who carry the AD risk gene E4 paradoxically improve after acute HFF. The investigators propose to further study this phenomenon with a clinical study to assess cerebral blood flow which can be measured by a technique called arterial spin labeling (ASL) on an MRI and is tightly related to brain metabolism.
CONDITIONS
Official Title
Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 55 or older at the date of the screening visit
- Equal representation of APOE E4 carriers and non-carriers
- Strive for equal numbers of men and women; women must be post-menopausal for at least 1 year or have a medical equivalent such as hysterectomy
- Able to read and understand English
- Able to cognitively and physically give informed consent
- Able to undergo an MRI and ingest dairy products
You will not qualify if you...
- Diabetes requiring medication, including type 1 or type 2 diabetes treated with oral drugs or insulin; diet-controlled diabetes or pre-diabetes allowed
- Taking medication for hypertension, unless safe to stop for 2 weeks before the MRI visit as approved by primary care provider
- Significant lipid abnormalities requiring statin, bile acid resins, fibrates, or high dose niacin; must be willing to stop these medications 4 weeks before screening if not on secondary prevention
- Known dementia, use of dementia medications, or other neurological diseases affecting cognition like recent stroke or advanced Parkinson's
- Active untreated major depression, psychosis, mania, or active alcohol or drug abuse disorder
- Other serious illnesses that would make attending visits or tests difficult, such as unstable angina, severe lung or heart disease, active liver or kidney disease with cognitive symptoms, or active cancer undergoing treatment
- Major digestive disorders affecting fat absorption or allergies/intolerance to milk or dairy
- Contraindications to MRI such as incompatible metal implants or inability to lie still or flat for the MRI duration
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Washington Medical Center
Seattle, Washington, United States, 98195
Actively Recruiting
Research Team
A
Angela J Hanson, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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