Comparing How Plant and Animal Protein Meals Affect Appetite and Metabolism in Women With Polycystic Ovary Syndrome PCOS

What this Trial Is About

Polycystic ovary syndrome PCOS is a common hormone disorder in women that involves insulin resistance, high levels of male hormones, and issues with reproduction. Researchers are studying how different protein sources in meals affect blood sugar, insulin, and appetite in women with PCOS. This study focuses on comparing plant-based protein meals to animal-based protein meals to better understand their immediate effects on metabolism and appetite regulation in this group. Participants will receive two types of test meals after fasting overnight one meal with 30% energy from plant proteins and another with 30% energy from animal proteins. Each meal contains 350 to 400 calories and must be consumed within 10 minutes. Researchers will then measure appetite and metabolic responses, including energy use and blood markers, for four hours after each meal to compare the effects of the protein sources. During the study, women with PCOS will undergo these meal challenges while researchers collect data on energy expenditure, appetite, plasma amino acids, and appetite-related biomarkers at multiple time points up to 240 minutes after eating. The study is randomized and single-masked, with careful monitoring of participants responses. The trial aims to provide insights that may guide dietary recommendations to improve metabolic health in women with PCOS. Participation will last for the duration of the meal testing sessions.

Appetite Response to Meals With Different Protein Sources in Women With PCOS