Actively Recruiting
Comparative Meal Response to Plant vs. Animal Protein in Women With PCOS
Led by University of Arkansas, Fayetteville · Updated on 2025-09-02
30
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Polycystic ovary syndrome (PCOS) is a common hormone disorder in women that involves insulin resistance, high levels of male hormones, and issues with reproduction. Researchers are studying how different protein sources in meals affect blood sugar, insulin, and appetite in women with PCOS. This study focuses on comparing plant-based protein meals to animal-based protein meals to better understand their immediate effects on metabolism and appetite regulation in this group. Participants will receive two types of test meals after fasting overnight: one meal with 30% energy from plant proteins and another with 30% energy from animal proteins. Each meal contains 350 to 400 calories and must be consumed within 10 minutes. Researchers will then measure appetite and metabolic responses, including energy use and blood markers, for four hours after each meal to compare the effects of the protein sources. During the study, women with PCOS will undergo these meal challenges while researchers collect data on energy expenditure, appetite, plasma amino acids, and appetite-related biomarkers at multiple time points up to 240 minutes after eating. The study is randomized and single-masked, with careful monitoring of participants' responses. The trial aims to provide insights that may guide dietary recommendations to improve metabolic health in women with PCOS. Participation will last for the duration of the meal testing sessions.
CONDITIONS
Brief Title
Appetite Response to Meals With Different Protein Sources in Women With PCOS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Females ages 18-50 years
- Confirmed diagnosis of PCOS
- Body mass index (BMI) between 18.5 and 35 kg/m2
- Stable body weight for at least 3 months (+ 5 pounds)
- Willingness to consume both plant- and animal-based protein meals
You will not qualify if you...
- Smoking or use of nicotine products
- Smoking or use of marijuana products
- Food allergies or dietary restrictions incompatible with test meals
- Diagnosed diabetes (type 1 or 2)
- Use of medications that interfere with study outcomes (e.g., metformin, GLP-1 agonists, etc.)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day
Participants consume a 350-400 kcal meal containing 30% energy from plant protein sources after an overnight fast. Appetite and metabolic responses are measured for 240 minutes following the meal.
1 visit (in-person) with measurements over 240 minutes post meal
Duration - Single day
Participants consume a 350-400 kcal meal containing 30% energy from animal protein sources after an overnight fast. Appetite and metabolic responses are measured for 240 minutes following the meal.
1 visit (in-person) with measurements over 240 minutes post meal
Trial Site Locations
Total: 1 location
1
Center for Human Nutrition
Fayetteville, Arkansas, United States, 72704
Actively Recruiting
Research Team
J
Jamie I Baum, PhD
S
Sydney Boudrey, MS, RDN
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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