Actively Recruiting
APPI-Cost Trial for Perforated Appendicitis
Led by The University of Texas Health Science Center, Houston · Updated on 2025-12-11
346
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
N
National Center for Advancing Translational Sciences (NCATS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI irrigation, and to collect costs and clinical and patient-reported outcomes among patients with non-perforated appendicitis.
CONDITIONS
Official Title
APPI-Cost Trial for Perforated Appendicitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Plan to undergo appendectomy for acute appendicitis
- Enrolled in study preoperatively
- Intraoperative diagnosis of perforated appendicitis
You will not qualify if you...
- Preoperative hemodynamic instability requiring ongoing infusion of vasopressors
- Allergy to iodine
- Uncontrolled hyper- or hypothyroidism
- Renal dysfunction
- Pregnant or breastfeeding
- Primary language neither English nor Spanish
- Lack of functioning telephone or email account
- Incarcerated or in police custody
- Non-perforated appendicitis
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
D
Dalya M Ferguson, MD, MS
CONTACT
D
Debbie Nguyen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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