Actively Recruiting
Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children
Led by Boston Children's Hospital · Updated on 2026-05-12
330
Participants Needed
1
Research Sites
14 weeks
Total Duration
On this page
Sponsors
B
Boston Children's Hospital
Lead Sponsor
T
The Brett Boyer Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the impact of a clinical decision support system (CDSS) on children under 12 years old who are receiving mechanical ventilation after surgery for congenital heart disease (CHD). The study aims to see how the CDSS affects the length of time these children remain on mechanical ventilation. This is an observational, single-center study comparing patients using the CDSS with a historical group to determine if the system helps reduce ventilation duration. The CDSS is integrated into the T3 Visualization Platform, which collects and displays continuous data from the patient's monitors, ventilator, and lab results on a bedside computer updated every 5 seconds. It uses predictive algorithms to estimate risks related to heart output, ventilation, and acidosis. Medical teams review the CDSS recommendations twice daily during rounds to guide weaning and extubation decisions. If the clinical team chooses not to follow the CDSS advice, they provide reasons via a brief survey. Participants will be monitored from surgery up to 28 days afterward. Researchers will assess the duration of mechanical ventilation and track events such as unplanned extubations, use of noninvasive ventilation, reintubation within 48 hours of extubation, and how closely the clinical team follows CDSS recommendations. The study will collect data prospectively after starting the CDSS and compare it with retrospective data before its use.
CONDITIONS
Brief Title
Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children younger than 12 years old
- Have had cardiac surgery
- Receiving mechanical ventilation for 48 hours or more in the Cardiac Intensive Care Unit following surgery
You will not qualify if you...
- Premature infants born before 37 weeks' gestation
- Weigh less than 2 kilograms
- Dependence on baseline ventilator via tracheostomy or noninvasive positive pressure ventilation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Twice daily screenings during morning and evening rounds
Duration - Up to 28 days after cardiac surgery
Participants receiving mechanical ventilation will be monitored using a clinical decision support system (CDSS) integrated into the bedside T3 platform to inform ventilator weaning, extubation readiness assessments, and extubation decisions.
Twice daily reviews during clinical rounds
Duration - Up to 28 days after surgery
Participants are observed for outcomes such as duration of mechanical ventilation, unplanned extubation, reintubation, and use of noninvasive ventilation following extubation.
Monitoring during the 28 days post-surgery with assessments around extubation events
Trial Site Locations
Total: 1 location
1
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
D
Daniel L Hames, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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