Actively Recruiting
Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration
Led by McGill University Health Centre/Research Institute of the McGill University Health Centre · Updated on 2024-11-20
70
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this interventional study is determine if the future liver remnant can be optimized by improving liver function pre-operatively in patients who are scheduled for major hepatectomy. The main questions it aims to answer are: 1. Does high-dose insulin therapy improve liver function in the pre-operative setting? 2. What is the effect of high-dose insulin therapy on liver function and liver regeneration after a liver venous deprivation (LVD) procedure? 3. What is the relationship between volume hypertrophy and function in the regenerating liver? Participants will receive a 6-hour infusion of insulin and dextrose to maintain a hyperinsulinemic-normoglycemic state in the weeks prior to planned liver surgery to assess its effect on liver function measured by 99m-Tc-Mebrofenin hepatobiliary scintigraphy.
CONDITIONS
Official Title
Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years old
- Candidate for major liver resection
- Resectable colorectal liver metastasis
You will not qualify if you...
- Inability to give consent
- Type 1 diabetes mellitus
- Uncontrolled blood glucose levels (fasting level > 10 mmol/L)
- Unresectable colorectal liver metastasis
- Extrahepatic metastatic disease that is unresectable
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
McGill Univeristy Health Centre
Montreal, Quebec, Canada, H3A 1A1
Actively Recruiting
Research Team
J
Jennifer Kalil, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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