Study of High-Dose Insulin Therapy to Improve Liver Function and Regrowth Before Major Liver Surgery

What this Trial Is About

Researchers are studying whether high-dose insulin therapy can improve liver function before major liver surgery in patients with colorectal liver metastasis. The trial aims to understand if this therapy enhances liver function pre-operatively, its effects after a liver venous deprivation LVD procedure, and the relationship between liver volume growth and function during regeneration. This study is interventional and explores these effects using specialized liver imaging techniques. Participants will receive a 6-hour infusion of insulin and dextrose to maintain a stable blood sugar level before their planned liver surgery. The study has three groups one receiving insulin therapy before surgery, one receiving insulin therapy after LVD, and one group undergoing LVD without insulin treatment. Insulin dosing is carefully controlled with blood sugar monitoring every 15 minutes during the infusion. During the study, liver function and regeneration will be assessed using 99mTc-Mebrofenin hepatobiliary scintigraphy and CT scans at specific times before and after treatment. Researchers will measure liver function improvements within 24 hours or 7 days post-treatment depending on the group. Participants may be involved in imaging, blood glucose monitoring, and clinical evaluations throughout their participation, which continues until after their liver surgery and follow-up assessments.

Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration