Using Inhomogeneous Magnetisation Transfer MRI to Study Myelin Changes in Multiple Sclerosis Patients Aged 18 to 45

What this Trial Is About

Researchers are evaluating a new MRI technique called inhomogeneous Magnetisation Transfer ihMT to monitor myelin damage and repair in people with multiple sclerosis MS, especially at the disease onset. This technique aims to detect the processes of demyelination and remyelination in active brain lesions and may help assess the effects of remyelinating treatments. The study includes both patients with MS and healthy volunteers matched by age and sex. Participants will undergo ihMT MRI scans using devices operating at 1.5 Tesla and 3 Tesla magnetic field strengths. The study groups include patients with relapsing-remitting MS and healthy controls, each receiving the ihMT sequence to measure myelin changes in the brain. These scans are performed to compare the sensitivity of ihMT in detecting active and chronic lesions. The study does not involve randomization or blinding. During the study, participants will have MRI evaluations at the start and over one year to measure the ihMT ratio, magnetic transfer, and myelin water fraction. Researchers will also assess the predictive value of ihMT for disease progression. Safety and adherence to MRI procedures are monitored, and participants must provide informed consent and meet eligibility criteria. The overall study duration spans from 2018 to 2028, with outcome measurements planned at one year.

Application of ihMT MRI in Multiple Sclerosis