Actively Recruiting
Application of ihMT MRI in Multiple Sclerosis
Led by Assistance Publique Hopitaux De Marseille · Updated on 2024-08-06
85
Participants Needed
1
Research Sites
452 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The development of in vivo biomarkers sensitive to myelin disruption represents a major clinical need to be able to monitor the demyelination processes as well as the effect of remyelinating therapies in multiple sclerosis. The investigators recently proposed a technique, derived from the conventional magnetisation transfer (MT): inhomogeneous Magnetisation Transfer (ihMT). In preliminary studies, this simple-to-implement and robust technique has shown great sensitivity for evaluating the demyelination processes. The goal of the project is to evaluate the ability of ihMT to measure and describe the spontaneous demyelination and remyelination processes involved in active lesions in a population of patients with MS at the the disease onset.
CONDITIONS
Official Title
Application of ihMT MRI in Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult male or female aged 18 to 45 years
- Affiliated with health insurance coverage
- Signed a free and informed consent after receiving detailed and understandable information
- Diagnosed with relapsing-remitting multiple sclerosis according to McDonald 2010 criteria
- Disease duration less than 5 years
- May be treated or untreated with first-line disease modifying therapy
- Presence of at least one active lesion on initial brain MRI with post-Gadolinium injection
You will not qualify if you...
- Progressive forms of MS other than early relapsing-remitting (primary or secondary progressive)
- Usual contraindications for MRI such as pacemaker, metal shards, claustrophobia, or agitation
- Risk of non-compliance due to confusion, involuntary movements, or poor tolerance of prolonged supine position
- Unable to give informed consent because of confusion, lack of vigilance, or understanding problems
- Pregnancy or breastfeeding
- History of neurological or psychiatric conditions
- Under guardianship or trusteeship
AI-Screening
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Trial Site Locations
Total: 1 location
1
Assistance Publique Des Hotipaux de Marseille
Marseille, PACA, France, 13354
Actively Recruiting
Research Team
J
JEAN PELLETIER, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
4
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