Actively Recruiting
Application of Platelet-rich Plasma (PRP) in Reproductive Medicine
Led by The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Updated on 2025-02-18
300
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Female fertility is affected by many factors, such as ovarian function, fallopian tube patency, uterine environment, and mental state, among which the ovaries and endometrium are more important. In reproductive medicine, ovarian dysfunction, poor ovarian reaction, intrauterine adhesion, recurrent implantation failure, and thin endometrium are the five most common diseases that affect fertility. These five diseases lack effective treatment, and previous studies have shown that platelet-rich plasma is promising in treating these five diseases, so it is necessary to further explore the therapeutic effect and potential mechanism.
CONDITIONS
Official Title
Application of Platelet-rich Plasma (PRP) in Reproductive Medicine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged over 18 and under 40 years with premature ovarian insufficiency characterized by oligomenorrhea or amenorrhea for more than 4 months and specific hormone or follicle count criteria
- Women aged 40 or younger with poor ovarian response indicated by advanced age or risk factors, poor response in previous IVF cycle, or decreased ovarian reserve meeting at least two specific criteria
- Women diagnosed with intrauterine adhesion by hysteroscopy, showing symptoms like reduced menstrual flow, amenorrhea, pain, infertility, or recurrent miscarriage and desiring pregnancy
- Women with thin endometrium defined by endometrial thickness less than 7mm on specific days and desiring pregnancy
- Women under 40 years with repeated implantation failure after at least three failed embryo transfers of high-quality embryos
You will not qualify if you...
- Alanine aminotransferase levels more than 3 times the normal upper limit or estimated glomerular filtration rate less than 90 ml/min
- Having bleeding disorders such as hemophilia or taking anticoagulant or antiplatelet drugs
- Having serious mental illness, cardiovascular or cerebrovascular diseases, or malignant tumors
- Having poorly controlled diabetes or other systemic diseases
- History of drug abuse, alcoholism, or drug addiction
- Participation in other interventional clinical studies within the past six months
- Poor compliance with study requirements
- Any other conditions deemed unsuitable for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Yiwu, Zhejiang, China, 322000
Actively Recruiting
Research Team
Y
Youhua Lai
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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