Actively Recruiting
Application of Platelet-rich Plasma (PRP) in Reproductive Medicine for Female Fertility Disorders
Led by The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Updated on 2025-02-18
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Female fertility can be affected by several factors including ovarian function, fallopian tube health, the uterine environment, and mental state, with the ovaries and endometrium playing key roles. Common reproductive diseases impacting fertility include ovarian dysfunction, poor ovarian response, intrauterine adhesion, recurrent implantation failure, and thin endometrium. These conditions currently lack effective treatments, and platelet-rich plasma (PRP) shows promise, prompting further research into its effects and mechanisms. This study evaluates the use of platelet-rich plasma injections delivered via transvaginal or laparoscopic methods for ovarian diseases such as premature ovarian insufficiency and poor ovarian response. For uterine diseases including intrauterine adhesion, thin endometrium, and repeated implantation failure, PRP is administered through intrauterine perfusion or injections under the endometrium. The study focuses on monitoring the safety of PRP treatment up to three months post-enrollment. Participants are female patients aged 18 to 50 years diagnosed with one of the specified reproductive diseases. Their progress will be tracked through assessments of adverse and serious adverse events from enrollment through the three-month treatment period. Researchers will evaluate the safety of PRP injections and collect data to better understand its potential therapeutic effects in reproductive medicine.
CONDITIONS
Brief Title
Application of Platelet-rich Plasma (PRP) in Reproductive Medicine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged over 18 and under 40 years with premature ovarian insufficiency characterized by oligomenorrhea or amenorrhea over 4 months and specific hormone or follicle count criteria
- Women aged up to 50 years with poor ovarian response meeting at least two of three criteria including age, previous IVF response, and ovarian reserve markers
- Adult women diagnosed with intrauterine adhesion by hysteroscopy, with symptoms and desire to conceive
- Adult women with thin endometrium defined by thickness less than 7mm on specific cycle days and desire to conceive
- Women under 40 with repeated implantation failure after at least three embryo transfers of high-quality embryos
You will not qualify if you...
- Alanine aminotransferase levels more than three times the normal upper limit or estimated glomerular filtration rate below 90 ml/min
- Bleeding disorders or use of anticoagulant or antiplatelet drugs
- Serious mental illness, cardiovascular or cerebrovascular diseases, and malignant tumors
- Poorly controlled diabetes or other systemic diseases
- Drug abuse, alcoholism, or drug addiction
- Participation in other interventional clinical studies within the last six months
- Poor compliance or any other conditions unsuitable for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 3 months
Participants receive Platelet-Rich Plasma (PRP) injections for ovarian or uterine reproductive disorders.
Trial Site Locations
Total: 1 location
1
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Yiwu, Zhejiang, China, 322000
Actively Recruiting
Research Team
Y
Youhua Lai
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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