Actively Recruiting
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest The Lazarus-PEEP Trial
Led by University Hospital, Ghent · Updated on 2026-01-21
132
Participants Needed
7
Research Sites
35 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial focuses on adults who experience out-of-hospital cardiac arrest, where the heart suddenly stops beating. Researchers are studying whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes such as restarting the heart, survival rates, and neurological function compared to standard CPR without PEEP. This study is a phase 3 randomized trial addressing a gap in knowledge about ventilation during CPR and its impact on patient outcomes. Participants are randomly assigned to one of two groups: one receives CPR with PEEP set at 5 cm H2O using an adult resuscitation bag with a disposable PEEP valve, and the other receives standard CPR without PEEP using the same type of resuscitation bag but without the PEEP valve. Ventilation and airway pressures are monitored with specialized sensors during resuscitation by advanced life support medical teams. The study evaluates both effectiveness and safety, including potential side effects like increased chest pressure or lung injury. During the study, participants' return of spontaneous circulation (ROSC) is measured as the primary outcome. Secondary outcomes include survival to hospital admission and discharge, 30- and 90-day survival, and neurological function at discharge. Data on CPR quality and physiological measurements are collected. The trial follows participants from enrollment through hospital discharge or death, with detailed monitoring of outcomes and safety to guide future CPR guidelines.
CONDITIONS
Brief Title
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years and older
- Experienced a non-traumatic out-of-hospital cardiac arrest
- Receiving cardiopulmonary resuscitation from an advanced life support team
- Intubated and ventilated during resuscitation efforts
You will not qualify if you...
- Cardiac arrest in patients younger than 18 years
- Traumatic cardiac arrest including drowning, penetrating or blunt injury, and burns
- Immediate return of spontaneous circulation before intubation
- Pregnancy
- Already receiving mechanical ventilation at the time of cardiac arrest for other reasons
- Existing do not resuscitate (DNR) orders or advanced directives against CPR
- Failure to intubate
- Currently enrolled in another interventional clinical trial that could interfere with this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Screening and enrollment visit
Duration - Until return of spontaneous circulation or end of resuscitation efforts
Participants receive ventilation during cardiopulmonary resuscitation (CPR) for out-of-hospital cardiac arrest using either a resuscitation bag with a disposable PEEP valve set at 5 cm H2O or a resuscitation bag without a PEEP valve.
1 treatment event during resuscitation
Duration - Up to 90 days after enrollment
Participants are monitored for survival and neurological outcomes up to 90 days after enrollment.
Follow-up assessments at hospital admission, discharge, 30 days, and 90 days
Trial Site Locations
Total: 7 locations
1
AZ Oostende
Ostend, West-Flandres, Belgium, 8400
Actively Recruiting
2
AZORG: campus Merestraat
Aalst, Belgium, B-9300
Actively Recruiting
3
AZORG: Campus Moorselbaan
Aalst, Belgium, B-9300
Actively Recruiting
4
AZORG: campus Geraardsbergen
Geraardsbergen, Belgium, B-9500
Actively Recruiting
5
UZ Ghent
Ghent, Belgium, B-9240
Actively Recruiting
6
AZ Zeno
Knokke, Belgium, 8300
Actively Recruiting
7
Centre hospitalier universitaire (CHU) Besançon-Franche-Comté
Besançon, France
Active, Not Recruiting
Research Team
T
Thomas Tackaert, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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