Actively Recruiting
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
Led by University Hospital, Ghent · Updated on 2026-01-21
132
Participants Needed
7
Research Sites
92 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition where the heart suddenly stops beating. PEEP is used during ventilation, which may enhance oxygen levels by keeping the airways open throughout CPR. This study aims to determine if using PEEP during CPR helps restart the heart more effectively, improves survival rates, and enhances survival with good neurologic outcomes after a cardiac arrest compared to standard CPR without PEEP. Researchers will randomly assign participants to one of two groups: one receiving CPR with PEEP set at 5 cm of water pressure and the other receiving standard CPR without PEEP. Participants will be treated by emergency medical teams trained in advanced life support, and specialised sensors will measure airflow and airway pressure during resuscitation. Additionally, the study will evaluate potential side effects associated with PEEP, such as increased pressure within the chest or lung injuries. Findings from this trial will guide recommendations on the usage of PEEP in standard CPR practices to potentially improve patient outcomes.
CONDITIONS
Official Title
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years and older
- Experienced non-traumatic out-of-hospital cardiac arrest
- Receiving cardiopulmonary resuscitation from an advanced life support team
- Intubated and ventilated during resuscitation efforts
You will not qualify if you...
- Cardiac arrest in patients younger than 18 years
- Traumatic cardiac arrest including drowning, penetrating or blunt injury, and burns
- Return of spontaneous circulation before intubation and ventilation
- Pregnancy
- Already on mechanical ventilation before cardiac arrest
- Existing do not resuscitate orders or advanced directives against CPR
- Failure to intubate successfully
- Currently enrolled in another interventional clinical trial that could affect outcomes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
AZ Oostende
Ostend, West-Flandres, Belgium, 8400
Actively Recruiting
2
AZORG: campus Merestraat
Aalst, Belgium, B-9300
Actively Recruiting
3
AZORG: Campus Moorselbaan
Aalst, Belgium, B-9300
Actively Recruiting
4
AZORG: campus Geraardsbergen
Geraardsbergen, Belgium, B-9500
Actively Recruiting
5
UZ Ghent
Ghent, Belgium, B-9240
Actively Recruiting
6
AZ Zeno
Knokke, Belgium, 8300
Actively Recruiting
7
Centre hospitalier universitaire (CHU) Besançon-Franche-Comté
Besançon, France
Active, Not Recruiting
Research Team
T
Thomas Tackaert, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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