Comparing Remimazolam, Dexmedetomidine, and Esketamine for Sedation Before Surgery in Children Ages 2 to 5

What this Trial Is About

This research aims to compare the effects of three drugs used for sedation before surgery in children aged 2 to 5 years. It focuses on finding the best medication plan to provide safer, more effective, and personalized sedation options for young patients. The study also examines how these drugs affect agitation after surgery, helping improve overall management of pediatric anesthesia. Participants will be randomly assigned to one of three groups receiving different drugs remimazolam at 0.3 mgkg, dexmedetomidine at 1 gkg, or esketamine at 0.5 mgkg. Each drug is given through an intravenous line before the child enters the operating room, with a parent present during administration. This study uses a triple-blind design to assess each drugs effects. During the study, researchers will monitor sedation success rate, time to sedation onset, and anxiety levels related to parent-child separation at multiple time points after drug injection. Additional assessments include mask acceptance, adverse reactions during sedation and anesthesia induction, restlessness during awakening, and vital signs such as heart rate, blood pressure, respiratory rate, and oxygen levels. The total participation covers the period before surgery and immediate recovery, providing detailed data on sedation and safety.

Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation