Actively Recruiting
Application of Thoracic Epidural SCS for Managing FOG in Patients With Advanced Parkinson's Disease
Led by National Taiwan University Hospital · Updated on 2025-11-20
5
Participants Needed
1
Research Sites
171 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Spinal cord stimulation (SCS) has proven to be effective for pain that is unresponsive to medication. This technique involves an anesthesiologist or a neurosurgeon placing stimulation electrodes at the thoracic vertebrae to provide pain relief. Although SCS is not currently a standard treatment for patients with Parkinson's disease, recent studies have shown that Parkinson's patients who experience intolerable pain and undergo SCS treatment not only experience pain relief but also show improvements in gait and other Parkinson's symptoms. Therefore, the investigators aim to use temporary, minimally invasive SCS electrodes to help patients with nrFOG (non-responsive Freezing of Gait) improve their stability and reduce their risk of falls.
CONDITIONS
Official Title
Application of Thoracic Epidural SCS for Managing FOG in Patients With Advanced Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 40 and 85 years old
- Diagnosed with primary Parkinson's disease by a movement disorder specialist for more than 5 years
- Has freezing of gait not controlled by medication
- May have lower limb pain with or without Parkinson's non-motor symptoms
- No other secondary gait problems
You will not qualify if you...
- Diagnosed with atypical Parkinson's disease
- Has spinal cord injuries
- Freezing of gait controlled by medication
- Presence of lesions near implantation area causing spinal canal stenosis or myelopathy
- Previous surgery or infection near implantation area that may affect implantation
- Abnormal blood clotting or cannot stop antithrombotic drugs shortly
- Clinical Dementia Rating Scale greater than or equal to 2.8
- Allergy to developer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital Hsin-Chu Branch
Hsinchu, Hsinchu City, Taiwan, 300
Actively Recruiting
Research Team
K
Kai-Hsiang Chen, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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