Actively Recruiting
The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron Hyperexcitability
Led by University of Lausanne · Updated on 2023-11-28
110
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
Sponsors
U
University of Lausanne
Lead Sponsor
S
Swiss National Science Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
In the present project, the investigators aim at proposing innovative ways of investigating spinal motoneuron hyperexcitability to counteract the associated impairments by using wide pulse high frequency neuromuscular electrical stimulation (WPHF NMES) in various populations. The investigators will use WPHF NMES contractions as a model to gain insights into the mechanisms underlying muscle cramps, restless legs syndrome or stroke-induced spasticity as there is evidence that they share common underlying mechanisms. The investigators will then use WPHF NMES as a training modality to improve plantar flexor neuromuscular function in stroke patients by taking advantage of their motoneuronal hyperexcitability.
CONDITIONS
Official Title
The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron Hyperexcitability
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of first-ever stroke (ischemic or hemorrhagic) with unilateral motor deficits for at least 6 months confirmed by medical records or imaging
- Inadequate ankle control during gait defined as ankle dorsiflexion less than 5° during stance phase and 0° during swing phase
- Passive ankle dorsiflexion range of motion at least to neutral position
- Ability to walk at least 10 meters with or without assistive devices
- Spasticity at the triceps surae with Modified Ashworth Score ≥1
- Availability and willingness to participate during the study period
- No contraindication to neuromuscular electrical stimulation
- Reporting nocturnal muscle cramps (for cramp-prone participants)
- Not currently treated for muscle cramps
- Diagnosis of primary restless legs syndrome (RLS) meeting all five IRLSSG criteria
- Diagnosis of primary RLS with at least one of: periodic limb movements, dopaminergic treatment response, family history, or lack of profound daytime sleepiness
- No neurological disease (for healthy participants)
- Being available and willing to participate during the study period
You will not qualify if you...
- Surface sensory loss of the affected lower leg as shown by inability to feel 60-g touch with Semmes-Weinstein monofilament
- Inability to understand study instructions or provide informed consent
- History of orthopedic or neurological disorders affecting walking
- History of surgery to correct drop foot (ankle fixation)
- Use of antispastic medications such as baclofen, tizanidine, tolperisone, benzodiazepines, dantrolene, or botulinum toxin to the plantar flexor muscles in the last 6 months
- Being treated for muscle cramps (for muscle cramp group)
- Symptoms solely explained by other medical or behavioral conditions rather than RLS
- Contraindications to neuromuscular electrical stimulation
- Presence of neurological disease (for healthy participants group exclusion)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Bâtiment Synathlon, quartier UNIL-Centre
Lausanne, Switzerland, 1015
Actively Recruiting
Research Team
N
Nicolas Place, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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