Studying Passive and Active Exercise Effects Using pGz and Cardiopulmonary Testing in Patients with Primary Mitochondrial Disease and Healthy Volunteers

What this Trial Is About

Researchers are evaluating the effects of conventional exercise and passive exercise through periodic acceleration pGz in individuals with primary mitochondrial disease PMD and healthy volunteers, as well as exploring these effects in patients admitted to a pediatric intensive care unit PICU. This multi-aim study compares responses between PMD patients and healthy controls, and also investigates outcomes in critically ill pediatric patients. Participants in Aim 1 will complete three study visits in random order, each involving a different intervention Cardiopulmonary Exercise Testing CPET, pGz via a bed device, and pGz via a Gentle Jogger device. Aim 2 participants in the PICU will have two study visits during their admission, involving pedal exercise and pGz using the Gentle Jogger. Interventions include exercise testing, passive exercise with devices, and administration of a contrast agent during vascular ultrasound. During study visits, participants will have blood draws before and after interventions, vascular ultrasounds with contrast, and MRI scans of the lower leg. Various measurements such as oxygen consumption, heart rate, plasma lactate levels, and vasodilation will be assessed. The study also includes surveys and scales to evaluate participant responses. Total participation involves multiple visits with detailed monitoring and assessments under medical supervision.

Applying pGz in Mitochondrial Disease