Actively Recruiting
Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery
Led by IWK Health Centre · Updated on 2026-04-27
100
Participants Needed
1
Research Sites
128 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research trial will measure how useful Aprepitant is in preventing nausea and vomiting in children having surgery to correct scoliosis (curvature of the spine).
CONDITIONS
Official Title
Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Posterior spinal instrumentation and fusion for idiopathic scoliosis
- Fusion includes at least 6 vertebral levels
- Children aged 8 years or older and younger than 19 years on surgery day
- Weight greater than 40 kg for pharmacy preparation purposes
You will not qualify if you...
- Patient or parent refusal to participate
- Allergy or adverse reaction to Aprepitant or its ingredients
- Developmental delay reported by parents
- Pregnancy confirmed by pre-operative test
- Severe systemic disease with ASA classification III or higher
- Use of medications that strongly interact with Aprepitant
- Neuromuscular or congenital scoliosis diagnosis
- Inability to take oral medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IWK Health Sciences Center
Halifax, Nova Scotia, Canada, B3K 6R8
Actively Recruiting
Research Team
M
Mathew Kiberd, MD
CONTACT
T
Tristain Dumbarton, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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