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Chemical and Protein Analysis of Eye Fluids and Tissues in Patients With Glaucoma and Cataracts
Led by Military Institute od Medicine National Research Institute · Updated on 2026-03-10
40
Participants Needed
2
Research Sites
44 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are assessing molecular and elemental differences in the eye fluids and tissues of people with primary open-angle glaucoma POAG and cataract compared to those with cataract only. This observational study aims to find chemical and protein patterns linked to glaucoma that might help with diagnosis or predicting disease progression. Participants undergo standard cataract or combined cataract and glaucoma surgery, during which samples of eye fluid and tissues are collected for analysis. The study groups include a glaucoma plus cataract group receiving combined surgery with deep sclerectomy, and a control group undergoing cataract surgery alone. Researchers use advanced laboratory methods to study proteins and elements in these samples. Throughout about one year of follow-up, participants have eye pressure measurements, vision tests, nerve layer imaging, and visual field exams. Researchers track protein expression and eye structure changes to understand glaucoma better. Data on medications used are also collected. This comprehensive evaluation helps explore potential glaucoma biomarkers and disease mechanisms.
CONDITIONS
Brief Title
Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract
Research Team
M
Marek Rękas, MD, PhD
W
Wojciech Mazurek, MD
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