Actively Recruiting
Integrated Chemical and Proteomic Analysis of Aqueous Humor and Ocular Tissues in Glaucoma and Cataract Patients
Led by Military Institute od Medicine National Research Institute · Updated on 2026-03-10
40
Participants Needed
2
Research Sites
44 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are assessing molecular and elemental differences in the eye fluids and tissues of people with primary open-angle glaucoma (POAG) and cataract compared to those with cataract only. This observational study aims to find chemical and protein patterns linked to glaucoma that might help with diagnosis or predicting disease progression. Participants undergo standard cataract or combined cataract and glaucoma surgery, during which samples of eye fluid and tissues are collected for analysis. The study groups include a glaucoma plus cataract group receiving combined surgery with deep sclerectomy, and a control group undergoing cataract surgery alone. Researchers use advanced laboratory methods to study proteins and elements in these samples. Throughout about one year of follow-up, participants have eye pressure measurements, vision tests, nerve layer imaging, and visual field exams. Researchers track protein expression and eye structure changes to understand glaucoma better. Data on medications used are also collected. This comprehensive evaluation helps explore potential glaucoma biomarkers and disease mechanisms.
CONDITIONS
Brief Title
Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Scheduled for cataract surgery with intraocular lens implantation
- Able to provide written informed consent
- For glaucoma group: diagnosed with primary open-angle glaucoma and cataract, planned combined cataract and glaucoma surgery
- For control group: cataract without glaucoma or other significant eye diseases
You will not qualify if you...
- Under 18 years old
- Pregnant or breastfeeding
- Advanced vision loss in the study eye (worse than counting fingers)
- Glaucoma types other than primary open-angle glaucoma
- Previous eye surgery in the study eye, including glaucoma surgery, vitreoretinal surgery, corneal transplant, or refractive surgery
- Active or past uveitis
- Other major chronic eye diseases in the study eye aside from cataract and primary open-angle glaucoma
- Unable to follow study procedures or attend follow-up visits
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants undergo standard cataract surgery with or without glaucoma surgery. During surgery, samples of aqueous humor and ocular tissues are collected for research analyses.
1 surgery visit (in-person)
Duration - Up to 1 year
Participants are monitored through regular clinical assessments including intraocular pressure, visual field, and retinal imaging for about 1 year after surgery.
Multiple follow-up visits over 1 year
Trial Site Locations
Total: 2 locations
1
Military Institute of Medicine - National Research Institute
Warsaw, Poland
Actively Recruiting
2
University of Warsaw
Warsaw, Poland
Actively Recruiting
Research Team
M
Marek Rękas, MD, PhD
W
Wojciech Mazurek, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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