Actively Recruiting
ARC101 in Advanced Solid Tumors
Led by Third Arc Bio · Updated on 2026-04-03
70
Participants Needed
12
Research Sites
181 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of ARC101 in patients with advanced cancer.
CONDITIONS
Official Title
ARC101 in Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Locally advanced or metastatic solid tumor ovarian, testicular or other Claudin 6+ cancers
- Measurable or evaluable disease, per RECIST v1.1
- Eastern Cooperative Oncology Group (ECOG) performance status 0-1
- Adequate organ function
You will not qualify if you...
- Active central nervous system involvement
- Diagnosis of a different malignancy within 2 years prior to study drug
- Uncontrolled ascites
- Toxicity from prior anticancer therapy not improved to Grade 1 or baseline
- Significant lung problems
- Active autoimmune disease within 12 months prior to study drug
- Pregnancy, breastfeeding, or plans for pregnancy or fathering a child during or within 90 days after treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
2
START Midwest
Grand Rapids, Michigan, United States, 49546
Actively Recruiting
3
START San Antonio, LLC.
San Antonio, Texas, United States, 78229
Actively Recruiting
4
Sunshine Coast University Private Hospital
Birtinya, Queensland, Australia, 4575
Actively Recruiting
5
Cancer Research SA
Adelaide, South Australia, Australia, 5000
Actively Recruiting
6
Cabrini Health Research
Malvern, Victoria, Australia, 3144
Actively Recruiting
7
BC Cancer Research Centre
Vancouver, British Columbia, Canada, V5Z 0B4
Actively Recruiting
8
The Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2C4
Actively Recruiting
9
McGill University Health Centre
Montreal, Quebec, Canada, H4A 0B1
Actively Recruiting
10
Rambam Medical Center
Haifa, Israel, 3109601
Actively Recruiting
11
Sheba Medical Center
Ramat Gan, Israel, 52621
Actively Recruiting
12
Sourasky Medical Center
Tel Aviv, Israel, 6423906
Actively Recruiting
Research Team
V
VP Clinical Operations
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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