Actively Recruiting
Arginine Metabolism in Youth With Type 2 Diabetes
Led by Baylor College of Medicine · Updated on 2026-01-27
30
Participants Needed
1
Research Sites
238 weeks
Total Duration
On this page
Sponsors
B
Baylor College of Medicine
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Type 2 diabetes (T2D), once considered only "a disease of older ages," is now a significant public health concern in youth. Although it is characterized by insulin resistance and impaired insulin secretion, its precise etiology and pathogenesis are not yet fully understood. This study aims to (1) explore arginine metabolism in youth with T2D via safe, minimally invasive kinetic experiments using stable isotope tracers and targeted metabolomics, and (2) determine the effect of exogenous arginine administration on β-cell function in youth with T2D, potentially supporting the use of this safe, low-cost, and readily available nutrient to improve pediatric diabetes outcomes.
CONDITIONS
Official Title
Arginine Metabolism in Youth With Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Youth with type 2 diabetes and healthy controls meeting the study's other criteria
- Girls aged 12 to 20 years who have started menstruating (postmenarchal)
- Boys aged 14 to 20 years who are at Tanner stage 5 genital development
- Youth with type 2 diabetes must have a diagnosis and diabetes duration between 3 months and 10 years
You will not qualify if you...
- Previous history of diabetic ketoacidosis (DKA)
- Poorly controlled diabetes with HbA1c greater than 7.5%
- Abnormal liver, thyroid, gonadal, or adrenal function
- Renal insufficiency with eGFR less than 90 mL/min/1.73 m2
- Use of glucose-lowering medications other than metformin, insulin, and liraglutide
- Use of any medication likely to interfere with amino acid metabolism
- Use of any hormonal replacement therapy
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Texas Children's Hospital / Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
M
Mustafa Tosur, MD
CONTACT
L
Lori Malone
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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