Comparing Three Catheter Ablation Methods Using Dual-Energy Lattice-Tip Catheter for Persistent Atrial Fibrillation

What this Trial Is About

Researchers are evaluating three different catheter ablation strategies for patients with persistent atrial fibrillation using a special lattice-tip catheter that can switch between radiofrequency ablation RFA and pulsed field ablation PFA energy. The study aims to determine if adding posterior wall isolation and mitral isthmus ablation improves freedom from atrial fibrillation over 12 months. This randomized clinical trial compares these approaches to find the most effective treatment combinations for this heart rhythm condition. Patients will be randomly assigned to one of three treatment groups pulmonary vein isolation using PFA energy alone pulmonary vein isolation plus posterior wall isolation using PFA energy or pulmonary vein isolation combined with posterior wall isolation using PFA and mitral isthmus ablation with either RFA or PFA energy. An implantable loop recorder will be placed before, during, or shortly after the ablation procedure to continuously monitor for any return of atrial fibrillation, atrial tachycardia, or atrial flutter. Participants will be monitored for 12 months with regular evaluations to assess treatment success, defined mainly by freedom from primary effectiveness failure. The study includes baseline and follow-up assessments including implantable device monitoring. Safety and outcome data will help understand the benefits and risks of the different ablation strategies. The total study duration for each participant is one year following the ablation procedure.

ARIADNE Clinical Trial