Actively Recruiting
Aromatherapy Inhaler Use for Hematopoietic Stem Cell Transplant Patient Distress
Led by Stanford University · Updated on 2026-06-02
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This trial focuses on patients undergoing hematopoietic cell transplantation (HCT) who often experience high distress during the early inpatient period. Researchers are evaluating whether using an inhaled aromatherapy stick during this acute phase is feasible and acceptable. The study also explores short-term changes in patient-reported cancer-related distress and coping confidence. Participants are randomly assigned to one of two groups. One group receives standard supportive inpatient care without aromatherapy. The other group receives standard care plus education on using an aromatherapy inhaler and an aromatherapy stick for self-administered inhalation, targeted for Transplant Day +1, +2, or +3. Aromatherapy use is recorded with a log and limited to a maximum total exposure time of two hours. During the study, participants report their distress levels using the NCCN Distress Thermometer and coping self-efficacy with a modified Cancer Behavior Inventory. Aromatherapy use and experience are tracked through logs and evaluations. Measurements are taken at baseline and at study completion, which occurs between Transplant Day +2 and +6, depending on timing. The study monitors these outcomes to assess feasibility, acceptability, and short-term patient-reported effects over a few days after transplant.
CONDITIONS
Brief Title
Aromatherapy Inhaler Use for HSCT Distress
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults over 18 years of age
- Patients admitted for planned autologous or allogeneic hematopoietic stem cell transplant (HSCT)
- Diagnosis of hematologic malignancy requiring HSCT
- Received chemotherapy during preparative regimen
- No allergies to lavender or peppermint essential oils
- Able to speak, read, and understand English
- Willing and capable of providing informed consent
You will not qualify if you...
- Patients admitted for Chimeric Antigen Receptor T cell (CART) infusion
- Patients receiving transplant for germ cell tumor diagnosis
- Unexpected or unplanned hospital admission (e.g., neutropenic fever, confusion, clinical deterioration)
- History of immune effector cell-associated neurotoxicity syndrome (ICANS) grade 1 through 4
- History of scleroderma
- History of atrial fibrillation
- Known G6PD deficiency
- Allergic to lavender or peppermint essential oils
- Pediatric patients 18 years of age or younger
- Unable to speak, read, and understand English
- Unwilling or incapable of providing informed consent
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Approximately 4 to 6 days post-transplant
Participants receive standard inpatient supportive care during hospitalization. Those assigned to the aromatherapy group also receive education and use an aromatherapy inhaler for self-administered inhalation on a designated day shortly after transplant. Aromatherapy use is tracked with a log and limited to a maximum total exposure time of 2 hours.
1 baseline visit on transplant day plus daily visits during early post-transplant inpatient period
Trial Site Locations
Total: 1 location
1
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
Research Team
A
Anna Oh, PhD, MPH, RN
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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