Actively Recruiting
Arsenic Trioxide With MAPK Inhibitors and Chemotherapy for Stage 4/M Neuroblastoma
Led by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Updated on 2025-04-18
92
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective, single-arm, multi-center clinical trial aims to explore and evaluate the efficacy and safety of the combination therapy involving arsenic trioxide, MAPK inhibitors, and chemotherapy for stage 4/M neuroblastoma.
CONDITIONS
Official Title
Arsenic Trioxide With MAPK Inhibitors and Chemotherapy for Stage 4/M Neuroblastoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a pathological diagnosis of neuroblastoma.
- Preoperative staging as INRG M stage or postoperative staging as INSS stage 4 (regardless of risk classification).
- Age 18 months to 18 years.
- Informed consent obtained from the legal guardian with a signed consent form.
You will not qualify if you...
- History of other tumors treated with chemotherapy and abdominal radiation therapy.
- Severe progressive or persistent heart failure: NYHA class III or IV or left ventricular ejection fraction below 50%.
- Severe progressive or persistent kidney failure: glomerular filtration rate below 30 ml/(min·1.73 m²) or serum creatinine above 5 mg/dL (442 µmol/L).
- Severe liver dysfunction: AST or ALT levels at least 5 times the upper limit of normal or total bilirubin at least 3 times the upper limit of normal.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sun Yat-sen Memorial Hospital
Guangzhou, Guangdong, China, 510120
Actively Recruiting
Research Team
Y
Yang Li, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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