Actively Recruiting
Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity
Led by VA Office of Research and Development · Updated on 2025-11-14
50
Participants Needed
1
Research Sites
239 weeks
Total Duration
On this page
Sponsors
V
VA Office of Research and Development
Lead Sponsor
U
University of Missouri-Columbia
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study will assign participants to take either the medication, empagliflozin or a placebo for 12 weeks. The goal of the study is to determine the effects of empagliflozin on arterial health in Veterans with obesity.
CONDITIONS
Official Title
Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body mass index (BMI) 30-45 kg/m2
- 30-60 years of age at randomization
- Evidence of arterial stiffening (defined as Carotid femoral PWV > age-predicted) at screening visit
You will not qualify if you...
- Unable to provide consent
- Diabetes mellitus
- Uncontrolled hypertension (>180/90mmHg) or systolic <100mmHg at screening visit
- Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease or stroke
- Diagnosis of chronic kidney disease
- Active cancer (excluding basal cell carcinoma or stage 1 squamous cell carcinoma of the skin)
- Excessive alcohol consumption (>14 drinks/week for men, >7 drinks/week for women)
- Use of GLP-1 analogs or SGLT2 inhibitors
- Use of hormone replacement therapy
- Use of pharmacological therapy for weight loss
- Body weight changes >10% within the past 6 months
- History of hypersensitivity to nitrates
- History of ketoacidosis
- History of recurrent UTIs or mycotic genital infections
- Use of anticoagulants
- Change in anti-hypertensive medication regimen (if in use) during the last 90 days
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Harry S. Truman Memorial, Columbia, MO
Columbia, Missouri, United States, 65201-5275
Actively Recruiting
Research Team
J
Jaume Padilla Parellada, PhD
CONTACT
K
Katherine M Burr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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