Actively Recruiting
Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell Disease
Led by The University of The West Indies · Updated on 2023-03-01
34
Participants Needed
1
Research Sites
173 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Structural and functional changes in arteries are increasingly being recognized as significant features of sickle cell disease. This study aims to determine whether there are differences in arterial function parameters between children with sickle cell disease with normal and abnormal transcranial Doppler velocity. After informed consent is obtained, participants will have vascular, Transcranial Doppler, haematological and biochemical parameters measured. Researchers will compare children with sickle cell disease who have normal Transcranial Doppler velocity and no history of stroke with children with those who have an abnormal Transcranial Doppler velocity with or without a history of stroke to see if there are significant differences in arterial function parameters.
CONDITIONS
Official Title
Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pediatric participants with sickle cell anaemia (HbSS, HbSβ0 thalassemia, HbSD, HbSOArab)
- Age between 4 and 16 years at the time of enrollment
- Has had at least one complete Transcranial Doppler (TCD) study, regardless of hydroxyurea treatment or clinical trial participation
- Parent or guardian willing and able to provide informed consent and child gives assent
- Ability to comply with study-related evaluations
You will not qualify if you...
- Unable to complete a Transcranial Doppler (TCD) study
- Received an erythrocyte transfusion in the past two months
- Currently acutely ill or had an acute infection in the past two weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Caribbean Institute for Health Research, The University of the West Indies
Kingston, Saint Andrew Parish, Jamaica, KGN20
Actively Recruiting
Research Team
A
Angela E Rankine-Mullings, MB;BS
CONTACT
P
Professor Marvin Reid, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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