Study of Advanced Heart Pressure Wave Analysis to Track Recovery After Balloon Pulmonary Angioplasty in Adults with Chronic Thromboembolic Pulmonary Hypertension

What this Trial Is About

This research aims to understand if advanced heart pressure wave analysis methods called WIA and REPA can help track and predict health improvements in adults aged 18 to 85 with Chronic Thromboembolic Pulmonary Hypertension CTEPH undergoing Balloon Pulmonary Angioplasty BPA. It focuses on whether changes in these wave patterns relate to better walking ability, heart function, and quality of life, and if these new measures are better than standard heart pressure tests. Participants will receive standard BPA treatment as part of their usual care. During each BPA session, heart pressure waveforms are recorded using a catheter without extra invasive steps. Clinical assessments including 6-minute walking tests, blood tests, and heart ultrasounds are done before treatment, during BPA sessions, and about one month after the last BPA session. Participants also complete surveys about their physical activity and quality of life. Throughout the study, researchers will collect data on heart function, walking distance, biomarkers like NT-proBNP, and quality of life scores to evaluate clinical improvement. Advanced wave analysis is done during BPA sessions to measure wave energy and pressure components. Safety events related to BPA are monitored, and the study lasts through treatment and a follow-up period one month after the final BPA session.

Arterial Wave Energy Flux and Multidimensional Recovery in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Balloon Pulmonary Angioplasty