Actively Recruiting
Arterial Wave Energy Flux and Multidimensional Recovery in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Balloon Pulmonary Angioplasty
Led by Istanbul Mehmet Akif Ersoy Educational and Training Hospital · Updated on 2026-04-13
70
Participants Needed
1
Research Sites
111 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn if advanced heart pressure wave analysis (called WIA and REPA) can help track and predict clinical improvement in adults (aged 18-85) with Chronic Thromboembolic Pulmonary Hypertension (CTEPH) who are undergoing Balloon Pulmonary Angioplasty (BPA). The main questions it aims to answer are: Do changes in these advanced heart pressure wave patterns relate to improvements in a patient's walking distance, heart function, and overall quality of life after BPA treatment? Are these new measurements more effective than standard heart pressure tests at showing how much a patient has truly improved? Participants will: Undergo standard Balloon Pulmonary Angioplasty (BPA) sessions as part of their regular medical care for CTEPH. Have their heart pressure waves recorded through a catheter during the routine BPA procedure (this does not require any extra surgical steps). Complete walking tests (6-minute walk test), blood tests, and heart ultrasounds (echocardiography) before starting the treatment and after it is completed. Fill out short surveys regarding their daily physical activity and quality of life.
CONDITIONS
Official Title
Arterial Wave Energy Flux and Multidimensional Recovery in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Balloon Pulmonary Angioplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 85 years
- Confirmed diagnosis of Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and eligible for Balloon Pulmonary Angioplasty (BPA)
- Hemodynamics consistent with pre-capillary pulmonary hypertension measured by right heart catheterization
- Technically inoperable CTEPH or persistent/recurrent pulmonary hypertension after pulmonary endarterectomy (PEA)
- Ability to provide written informed consent
You will not qualify if you...
- Diagnosis of pulmonary hypertension other than CTEPH or severe parenchymal lung disease
- Active infection, uncontrolled systemic disease, active cancer, or life expectancy less than 12 months
- Pregnant or breastfeeding
- Advanced kidney failure (eGFR less than 30 mL/min/1.73 m²) or contraindication to contrast media
- Poor echocardiographic image quality preventing reliable analysis
- Pressure tracing artifacts or uncontrolled arrhythmias such as rapid atrial fibrillation
- Hemodynamically unstable or decompensated patients
- Any other condition considered unsuitable by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Istanbul, Turkey (Türkiye), 34303
Actively Recruiting
Research Team
U
Umit Bulut, MD
CONTACT
A
Ahmet Tas, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here