Actively Recruiting
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Led by Mayo Clinic · Updated on 2025-07-11
2100
Participants Needed
27
Research Sites
330 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
U
University of California, San Francisco
Collaborating Sponsor
AI-Summary
What this Trial Is About
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium to study FTLD for 2019 and beyond.
CONDITIONS
Official Title
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 years or older
- Familial FTLD participants must have a known disease-associated mutation in major FTLD genes (MAPT, GRN, C9orf72, or others) or an autosomal dominant family history of FTLD syndrome verified by medical records or family history
- Sporadic FTLD participants must have a symptomatic FTLD syndrome with no known family history or genetic mutation and meet research criteria for specific FTLD syndromes including PSP, svPPA, nfvPPA, CBD/CBS, bvFTD, or FTD/ALS
- Biofluid arm participants can be familial or sporadic FTLD meeting the above criteria and may be included regardless of primary language if translated consent is available
- Participants must be able to complete at least 75% of study procedures to enroll in the longitudinal arm
You will not qualify if you...
- Presence of a structural brain lesion (e.g., tumor, cortical infarct) that could explain symptoms
- Presence of Alzheimer’s disease causing mutation (PSEN1, PSEN2, APP) or biomarker evidence of Alzheimer’s disease
- History of Korsakoff encephalopathy, severe alcohol dependence within 5 years of dementia onset, frequent substance intoxication, or other neurological disorders
- Uncorrected B12 deficiency, unregulated hypothyroidism, HIV positive, renal failure, liver failure, respiratory failure requiring supplemental oxygen
- Large confluent white matter lesions or significant systemic illnesses such as worsening cardiovascular disease
- Current medication likely to affect central nervous system functions per site investigator
- Inability to complete sufficient key study procedures, though may be eligible for the biofluid arm if able to tolerate blood draw and brief exam
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 27 locations
1
University of Alabama Birmingham
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
University of California, Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
3
University of California, San Diego
San Diego, California, United States, 92093
Actively Recruiting
4
University of California San Francisco
San Francisco, California, United States, 91358
Actively Recruiting
5
University of Colorado Denver
Denver, Colorado, United States, 80204
Actively Recruiting
6
Mayo Clinic Florida
Jacksonville, Florida, United States, 32224
Actively Recruiting
7
Emory University
Atlanta, Georgia, United States, 30322
Actively Recruiting
8
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
9
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
10
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
11
NIH
Bethesda, Maryland, United States, 20814
Actively Recruiting
12
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
13
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
14
Mayo Clinic Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
15
Washinton University in St. Louis
St Louis, Missouri, United States, 63110
Actively Recruiting
16
Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, Nevada, United States, 89106
Actively Recruiting
17
Mount Sinai
New York, New York, United States, 10029
Not Yet Recruiting
18
Columbia University
New York, New York, United States, 10032
Actively Recruiting
19
University of North Carolina, Chapel Hill
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
20
Case Western Reserve Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
21
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
22
Vanderbilt University
Nashville, Tennessee, United States, 37235
Actively Recruiting
23
Nantz National Alzheimer Center Houston
Houston, Texas, United States, 77030
Actively Recruiting
24
UT San Antonio Health Science Center
San Antonio, Texas, United States, 78229
Actively Recruiting
25
University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
26
University of British Columbia
Vancouver, British Columbia, Canada
Actively Recruiting
27
University of Toronto
Toronto, Ontario, Canada
Actively Recruiting
Research Team
L
Leah K Forsberg, PhD
CONTACT
H
Hilary Heuer, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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