Study of Artichoke By-product Supplementation with a Mediterranean Diet to Prevent Type 2 Diabetes in Overweight Adults

What this Trial Is About

Researchers are evaluating whether taking a supplement made from artichoke by-products, which are rich in hydroxycinnamic acids HCAs, alongside an energy-restricted Mediterranean diet can improve blood sugar control, reduce insulin resistance, and support weight loss in adults who are overweight or obese. The study also aims to understand the biological mechanisms involved using advanced techniques and to identify biomarkers that may help tailor personalized nutrition strategies for preventing type 2 diabetes. Participants will be randomly assigned to one of two groups for a 16-week period. One group will follow an energy-restricted Mediterranean diet combined with physical activity guidance and take daily capsules containing artichoke by-product powder rich in HCAs. The other group will follow the same diet and physical activity plan but will take placebo capsules without HCAs. Both groups will receive personalized dietary counselling and recommendations to engage in at least 150 minutes of moderate physical activity each week. During the study, participants will attend clinical visits to monitor diet and exercise adherence, collect biological samples, and evaluate health outcomes. Researchers will measure changes in insulin resistance using HOMA-IR, body weight, glucose metabolism markers, lipid profiles, inflammatory and oxidative stress markers, and continuous glucose monitoring data. They will also use advanced molecular analyses to study gut microbiota, metabolomics, and DNA methylation. The study will last 16 weeks, with outcomes assessed from enrollment to the end of the intervention period.

Artichoke By-products Rich in Hydroxycinnamic Acids and Mediterranean Diet for Type 2 Diabetes Prevention.