The Effectiveness of Two Different Endometrial Preparation Regimens for Frozen Embryo Transfer in Women With Adenomyosis

What this Trial Is About

Researchers are evaluating two different protocols for preparing the uterus lining endometrium before frozen embryo transfer FET in women with adenomyosis undergoing IVFICSI. The study aims to find out if combining GnRH agonist and letrozole with hormone therapy leads to higher live birth rates compared to hormone therapy alone. It also looks at the side effects of the combined protocol. Adenomyosis, a condition where uterine tissue invades muscle layers, can cause infertility and pregnancy complications, and optimal preparation methods are unclear. Participants are randomly assigned to one of two groups. The first group receives two doses of GnRH agonist injections and daily letrozole over two months before starting hormone therapy with oral estradiol and vaginal progesterone. The second group receives hormone therapy alone starting early in the menstrual cycle with oral estradiol followed by vaginal progesterone once the uterine lining is thick enough. Embryo thawing and transfer are timed with progesterone start. Hormonal support continues until the 12th week of pregnancy. Participants undergo screening and ultrasound to confirm adenomyosis and monitor uterine lining thickness. Various pregnancy outcomes, including live birth rate at 22 weeks, pregnancy tests, implantation, miscarriage, and birth weight, are tracked. Side effects from the treatments and pregnancy complications like gestational diabetes and hypertension are also monitored. The study includes careful follow-up until delivery and newborn health assessments. Total participation duration covers preparation, pregnancy monitoring, and birth outcomes.

Artificial Cycle With or Without GnRH Agonist Pre-treatment for Frozen Embryo Transfer in Adenomyosis Patients