Actively Recruiting
Artificial Intelligence to Implement Cost-saving Strategies for Colonoscopy Screening Based on in Vivo Prediction of Polyp Histology
Led by Istituto Clinico Humanitas · Updated on 2023-10-04
1800
Participants Needed
2
Research Sites
205 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This three parallel-arms, randomized, multicenter trial is aimed at investigating the value of AI-assisted optical biopsy for differentiating between neoplastic and non-neoplastic polyps which will lead to the implementation of cost-saving strategies in screening programs. A cost-effectiveness analyses with the use of modern trial emulation analyses of large observational and clinical trial datasets and real-cost data will be conducted. To improve personalized treatment with a novel colonoscopy CADx risk-prediction tool, the investigators will even develop a novel deep learning algorithm for the optical biopsy of the alternative pathway of colorectal cancer carcinogenesis, namely the serrated pathway and develop cost-effectiveness models of AI-assisted optical biopsy in colorectal cancer screening that provides reliable information to identify cancer risk regardless of physicians' skill.
CONDITIONS
Official Title
Artificial Intelligence to Implement Cost-saving Strategies for Colonoscopy Screening Based on in Vivo Prediction of Polyp Histology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All patients aged over 40 years undergoing colonoscopy for selected reasons
You will not qualify if you...
- Personal history of colorectal cancer or inflammatory bowel disease
- Diagnosis of Lynch syndrome or Familial Adenomatous Polyposis
- Inadequate bowel preparation (Boston Bowel Preparation Scale less than 2 in any colon segment)
- Previous colon surgery
- Use of antithrombotic therapy preventing polyp removal
- Unable or unwilling to provide written informed consent
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Istituto Clinico Humanitas
Rozzano, Milano, Italy, 20089
Actively Recruiting
2
Istituto Clinico Humanitas
Rozzano, Milano, Italy, 20089
Actively Recruiting
Research Team
C
Cesare Hassan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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