Actively Recruiting
aSAH Treatment Based on Intraventricular ICP Monitoring: A Prospective, Multicenter, Randomized and Controlled Trial
Led by Huashan Hospital · Updated on 2025-01-07
372
Participants Needed
1
Research Sites
136 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
ASTIM is a multicenter, prospective, randomised, blinded end-point assessed trial, to investigate the efficacy and safety of treatment based on intracranial pressure monitoring in improving the prognosis of patients with aneurysmal subarachnoid hemorrhage.
CONDITIONS
Official Title
aSAH Treatment Based on Intraventricular ICP Monitoring: A Prospective, Multicenter, Randomized and Controlled Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of aneurysmal subarachnoid hemorrhage by symptoms and CT scan or lumbar puncture, with ruptured intracranial aneurysm confirmed by CTA or DSA
- Planned craniotomy clipping or endovascular treatment within 72 hours targeting a single procedure to treat the bleeding aneurysm
- Age 18 years or older
- Symptom onset within 72 hours
- Hunt-Hess grade between 2 and 4 and modified Fisher grade between 2 and 4 on CT imaging
- Signed informed consent from the patient and family members
You will not qualify if you...
- Pregnancy or breastfeeding
- Bilateral dilated pupils at admission
- Presence of tumors, bleeding disorders, or severe underlying conditions such as chronic obstructive pulmonary disease, multiple organ dysfunction syndrome, severe diabetes mellitus, congestive heart failure, or chronic kidney disease
- History of brain disorders or previous brain surgeries
- Bleeding caused by factors other than an aneurysm
- Aneurysmal rupture bleeding with moyamoya disease
- Other conditions affecting prognosis
- Volunteering specifically for ICP monitoring
- Participation in other ongoing clinical trials
- Any other situations judged inappropriate for inclusion by two physicians
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Neurosurgery, Huashan Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200000
Actively Recruiting
Research Team
X
Xuehai Wu, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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