Actively Recruiting
Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-01-23
500
Participants Needed
6
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Memorial Sloan Kettering Cancer Center
Lead Sponsor
M
Montefiore Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the genetic causes of Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, leukemia, and related blood cancers. The study focuses on families where one or more members have these lymphoproliferative disorders or related cancers, aiming to better understand inherited risks. This observational study is led by Memorial Sloan Kettering Cancer Center and looks to gather genetic information to aid research on these conditions. Participants include individuals with personal or family histories of lymphoma or related diseases. The study collects DNA samples and frozen lymphocytes to support genetic laboratory investigations. The goal is to build a collection that facilitates research into familial lymphoid cancers and to identify new genes that may predispose families to these diseases. The study includes patients and family members, including children, and involves broad eligibility criteria to encompass various types of lymphoproliferative diseases. During the study, participants provide biological samples for DNA storage and genetic analysis. Researchers verify diagnoses through medical records and family history questionnaires. The primary outcome is establishing a DNA and cell repository over 2 years, with secondary goals to perform genetic linkage and candidate gene studies. Participants may be followed for about 2 years, with no treatments involved. The study involves minimal risk and includes assessments of family history and genetic predisposition to lymphoid cancers.
CONDITIONS
Brief Title
Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals with a personal or family history of lymphoma, leukemia, multiple myeloma, or related lymphoproliferative diseases.
- Patients referred from outpatient clinics of Lymphoma, Multiple Myeloma, or Leukemia Services.
- Family members including siblings, children, grandparents, aunts, and uncles of affected individuals.
- Women with Hodgkin's disease who received therapeutic irradiation or developed secondary cancers.
- Minors may participate with assent and legal guardian consent.
- Patients with lymphoma associated with colon or renal cancer are eligible for DNA storage.
- Individuals previously consented to related genetic epidemiology studies may be included.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 years
Participants provide DNA and frozen lymphocyte samples for genetic laboratory investigations.
1 to 2 visits depending on family history and sample requirements
Duration - Up to 2 years
Participants are observed for genetic studies related to familial lymphoproliferative disorders.
Visits as needed for sample collection and genetic analysis updates
Trial Site Locations
Total: 6 locations
1
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Commack
Commack, New York, United States, 11725
Actively Recruiting
4
Memorial Sloan Kettering Westchester
Harrison, New York, United States, 10604
Actively Recruiting
5
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
6
Memorial Sloan Kettering Rockville
Rockville Centre, New York, United States, 11570
Actively Recruiting
Research Team
K
Kenneth Offit, MD
G
Gilles Salles, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here