Actively Recruiting
ASCVD Management Using CCTA in Prostate Cancer Patients on ADT
Led by Indiana University · Updated on 2026-02-25
100
Participants Needed
3
Research Sites
206 weeks
Total Duration
On this page
Sponsors
I
Indiana University
Lead Sponsor
N
National Comprehensive Cancer Network
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a randomized pilot study of Coronary CT Angiography (CCTA) for coronary atherosclerosis vs. Usual Care in patients with prostate cancer who are either planning to begin, or are currently taking androgen deprivation therapy (ADT) .
CONDITIONS
Official Title
ASCVD Management Using CCTA in Prostate Cancer Patients on ADT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent and HIPAA authorization for release of personal health information
- Age 40 years or older at time of consent
- Previous diagnosis of prostate cancer and currently receiving or planning to start ADT for more than 12 months
- Allowed if receiving ADT plus androgen pathway inhibitors such as abiraterone, enzalutamide, apalutamide, or darolutamide
- At least one risk factor for atherosclerotic cardiovascular disease (hypertension, hyperlipidemia, diabetes, tobacco use)
- No current cardiac symptoms
You will not qualify if you...
- Concurrent treatment with chemotherapy (docetaxel, cabazitaxel, mitoxantrone) at time of consent
- Presence of implantable cardioverter-defibrillator (ICD) or pacemaker
- History of coronary stents, obstructive coronary artery disease, myocardial infarction, coronary artery bypass grafting, or atrial fibrillation
- Renal dysfunction with creatinine clearance less than 35 ml/min
- Allergy to iodinated contrast
- Contraindication to medications used to regulate heart rate for CCTA scan (only for those in CCTA group)
- Taking sildenafil or tadalafil for vasodilation, pulmonary hypertension, or benign prostatic hyperplasia (BPH); taking these for erectile dysfunction is allowed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
IU Health Joe and Shelly Schwarz Cancer Center
Carmel, Indiana, United States, 46032
Actively Recruiting
2
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
3
Methodist Hospital
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
E
Elizabeth Rowe
CONTACT
A
Abhishek Khemka, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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